3-benzyloxy-N,N-diethyl-2R-methylpropionamide

Base Information

Chemical Name:3-benzyloxy-N,N-diethyl-2R-methylpropionamide
CAS No.:252898-26-3
Molecular Formula:C₁₅H₂₃NO₂
Molecular Weight:249.353
Hs Code.:

Synonyms:3-benzyloxy-N,N-diethyl-2R-methylpropionamide

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Chemical Property of 3-benzyloxy-N,N-diethyl-2R-methylpropionamide

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Technology Process of 3-benzyloxy-N,N-diethyl-2R-methylpropionamide

There total 1 articles about 3-benzyloxy-N,N-diethyl-2R-methylpropionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 56850-58-9,59965-24-1,74924-27-9,112068-34-5
methyl (2R)-3-(benzyloxy)-2-methylpropanoate

: 252898-26-3
3-benzyloxy-N,N-diethyl-2R-methylpropionamide

Guidance literature:: Multi-step reaction with 2 steps

1: 91 percent / aq. LiOH / tetrahydrofuran / 4 °C

2: 94 percent / 2-(1H-benzotriazol-1-yl)-1,1,3,3-tetramethyluronium*BF₄; diisopropylethylamine / CH₂Cl₂; acetonitrile / 2.5 h / 20 °C

With lithium hydroxide; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; acetonitrile; 1: Hydrolysis / 2: Condensation;
DOI:10.1021/ja991175f

Reference yield:

: 252898-26-3
3-benzyloxy-N,N-diethyl-2R-methylpropionamide

: 252898-32-1
3-(5S-isopropyl-4S-methoxycarbonyl-2-phenyl-4,5-dihydro-oxazol-4-yl)-3S-hydroxy-2R-methyl-N,N-diethylpropionamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: 100 percent / H₂; 10 percent Pd(OH)2/C / methanol / 60 h / 20 °C / 760 Torr

2.1: 88 percent / Dess-Martin periodinane / CH₂Cl₂ / 1 h / 20 °C

3.1: lithium bis(trimethylsilyl)amide / tetrahydrofuran; hexane / 0.75 h / -78.8 °C

3.2: dimethylaluminum chloride / tetrahydrofuran; hexane / 1 h / -78.8 °C

3.3: tetrahydrofuran; hexane / -85 - -20 °C

With palladium dihydroxide; hydrogen; Dess-Martin periodane; lithium hexamethyldisilazane; In tetrahydrofuran; methanol; hexane; dichloromethane; 1.1: Hydrogenation / 2.1: Oxidation / 3.1: Metallation / 3.2: Substitution / 3.3: Condensation;
DOI:10.1021/ja991175f