Technology Process of (Z)-5-[(1R,2R)-2-(2-{[(1S,2S)-1-carboxy-2-methylbutyl]amino}-2-oxoethyl)-5-oxocyclopentyl]pent-3-enoic acid
There total 1 articles about (Z)-5-[(1R,2R)-2-(2-{[(1S,2S)-1-carboxy-2-methylbutyl]amino}-2-oxoethyl)-5-oxocyclopentyl]pent-3-enoic acid which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
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Multi-step reaction with 7 steps
1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 1.5 h / 20 °C / Inert atmosphere
2: toluene-4-sulfonic acid / toluene / Reflux; Dean-Stark; Inert atmosphere
3: ozone; dimethylsulfide / methanol / 1.33 h / -78 - 20 °C / Inert atmosphere
4: potassium carbonate / methanol / 6 h / 20 °C / Inert atmosphere
5: copper(l) iodide / acetonitrile / 4 h / 20 °C / Inert atmosphere
6: nickel diacetate; sodium tetrahydroborate; hydrogen; ethylenediamine / ethanol / 6 h / Inert atmosphere
7: sodium hydroxide; water / methanol / 4 h / Reflux; Inert atmosphere
With
dmap; sodium tetrahydroborate; copper(l) iodide; dimethylsulfide; water; hydrogen; nickel diacetate; potassium carbonate; toluene-4-sulfonic acid; ozone; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; ethylenediamine; sodium hydroxide;
In
methanol; ethanol; dichloromethane; toluene; acetonitrile;
DOI:10.1002/ejoc.201403347
