(-)-2-cyclohexyl-2-hydroxyethylamine

Base Information

• Chemical Name: (-)-2-cyclohexyl-2-hydroxyethylamine
• CAS No.: 84619-59-0
• Molecular Formula: C₈H₁₇NO
• Molecular Weight: 143.229
• Mol file: 84619-59-0.mol

Synonyms:(-)-2-cyclohexyl-2-hydroxyethylamine

Chemical Property of (-)-2-cyclohexyl-2-hydroxyethylamine

Chemical Property:

Purity/Quality:

95-99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (-)-2-cyclohexyl-2-hydroxyethylamine

There total 7 articles about (-)-2-cyclohexyl-2-hydroxyethylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

(R)-2-cyclohexyl-2-hydroxyacetonitrile (4354-47-6,107485-34-7,100007-62-3) → (-)-2-cyclohexyl-2-hydroxyethylamine (84619-59-0)

Guidance literature:

With lithium aluminium tetrahydride; In diethyl ether; for 3h; Ambient temperature;

DOI:10.1055/s-1990-26945

Reference yield:

(R)-2-Amino-1-phenylethanol (2549-14-6,1936-63-6) → (-)-2-cyclohexyl-2-hydroxyethylamine (84619-59-0)

Guidance literature:

With hydrogenchloride; hydrogen; platinum(IV) oxide; In ethanol; for 7h; under 2585.7 Torr;

DOI:10.1021/jm00352a020

Reference yield:

(E)-ethyl 2-(1-cyclohexyl-2-nitroethoxyimino)acetate → (-)-2-cyclohexyl-2-hydroxyethylamine (84619-59-0)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethyl acetate; for 3.5h; under 11251.1 Torr;

DOI:10.1039/b707844g

upstream raw materials:

(R)-2-Amino-1-phenylethanol

(R)-2-cyclohexyl-2-hydroxyacetonitrile

(R)-2-Azido-1-cyclohexyl-ethanol

(R)-1-cyclohexylethane-1,2-diol

Downstream raw materials:

(2R)-(-)-1-tert-butoxycarbonylamino-2-cyclohexylethan-2-ol

Refernces

• 1、 Lohray, Braj B.,Ahuja, Jaimala R.. "Synthesis of Homochiral Amino Alcohols, Aziridines and Diamines via Homochiral Cyclic Sulphites". . p. 95 - 97. Retrieved 2007/10/02.
• 2、 Rafferty, Michael F.,Wilson, David S.,Monn, James A.,Krass, Polina,Borchardt, Ronald T.,Grunewald, Gary L.. "Importance of the Aromatic Ring in Adrenergic Amines. 7. Comparison of the Stereoselectivity of Norepinephrine N-Methyltransferase for Aromatic vs. Nonaromatic Substrates and Inhibitors". . p. 1198 - 1204. Retrieved 2007/10/02.