1-(2-bromobenzenesulfonyl)-3-(4-chloro-1-ethyl-2,5-dihydro-1H-pyrrol-3-yl)-1H-indole

Base Information

Chemical Name:1-(2-bromobenzenesulfonyl)-3-(4-chloro-1-ethyl-2,5-dihydro-1H-pyrrol-3-yl)-1H-indole
CAS No.:1325211-85-5
Molecular Formula:C₂₀H₁₈BrClN₂O₂S
Molecular Weight:465.798
Hs Code.:

Synonyms:1-(2-bromobenzenesulfonyl)-3-(4-chloro-1-ethyl-2,5-dihydro-1H-pyrrol-3-yl)-1H-indole

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Chemical Property of 1-(2-bromobenzenesulfonyl)-3-(4-chloro-1-ethyl-2,5-dihydro-1H-pyrrol-3-yl)-1H-indole

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Technology Process of 1-(2-bromobenzenesulfonyl)-3-(4-chloro-1-ethyl-2,5-dihydro-1H-pyrrol-3-yl)-1H-indole

There total 3 articles about 1-(2-bromobenzenesulfonyl)-3-(4-chloro-1-ethyl-2,5-dihydro-1H-pyrrol-3-yl)-1H-indole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1325212-64-3
C₁₄H₁₅ClN₂

: 2905-25-1
o-bromobenzenesulfonyl chloride

: 1325211-85-5
1-(2-bromobenzenesulfonyl)-3-(4-chloro-1-ethyl-2,5-dihydro-1H-pyrrol-3-yl)-1H-indole

Guidance literature:: C₁₄H₁₅ClN₂; With sodium hydride; In N,N-dimethyl-formamide; at 25 - 30 ℃; for 0.5h; Inert atmosphere;

o-bromobenzenesulfonyl chloride; In N,N-dimethyl-formamide; at 25 - 30 ℃; for 3h; Inert atmosphere;
DOI:10.1016/j.bmcl.2011.05.106

Reference yield:

: 20198-77-0
3,4-dichloro-1-ethyl-pyrrole-2,5-dione

: 1325211-85-5
1-(2-bromobenzenesulfonyl)-3-(4-chloro-1-ethyl-2,5-dihydro-1H-pyrrol-3-yl)-1H-indole

Guidance literature:: Multi-step reaction with 3 steps

1.1: magnesium; methyl iodide / tetrahydrofuran / 1 h / 25 - 30 °C / Inert atmosphere

1.2: 3 h / 70 °C / Inert atmosphere

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 4 h / Reflux

3.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 25 - 30 °C / Inert atmosphere

3.2: 3 h / 25 - 30 °C / Inert atmosphere

With lithium aluminium tetrahydride; sodium hydride; magnesium; methyl iodide; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2011.05.106

Reference yield:

: 1325212-50-7
C₁₄H₁₁ClN₂O₂

: 1325211-85-5
1-(2-bromobenzenesulfonyl)-3-(4-chloro-1-ethyl-2,5-dihydro-1H-pyrrol-3-yl)-1H-indole

Guidance literature:: Multi-step reaction with 2 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / 4 h / Reflux

2.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 25 - 30 °C / Inert atmosphere

2.2: 3 h / 25 - 30 °C / Inert atmosphere

With lithium aluminium tetrahydride; sodium hydride; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2011.05.106