ethyl N-methyl-N-(3-trifluoromethylphenyl)thiocarbamoylacetate

Base Information

• Chemical Name: ethyl N-methyl-N-(3-trifluoromethylphenyl)thiocarbamoylacetate
• CAS No.: 172896-57-0
• Molecular Formula: C₁₃H₁₄F₃NO₂S
• Molecular Weight: 305.321
• Mol file: 172896-57-0.mol

Synonyms:ethyl N-methyl-N-(3-trifluoromethylphenyl)thiocarbamoylacetate

Chemical Property of ethyl N-methyl-N-(3-trifluoromethylphenyl)thiocarbamoylacetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl N-methyl-N-(3-trifluoromethylphenyl)thiocarbamoylacetate

There total 1 articles about ethyl N-methyl-N-(3-trifluoromethylphenyl)thiocarbamoylacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

Monothiomalonsaeure-O,O-diethylester (16516-12-4) + N-methyl-3-(trifluoromethyl)aniline (2026-70-2) → ethyl N-methyl-N-(3-trifluoromethylphenyl)thiocarbamoylacetate (172896-57-0)

Guidance literature:

at 180 ℃;

DOI:10.1080/00397910008087354

Reference yield: 94.0%

ethyl N-methyl-N-(3-trifluoromethylphenyl)thiocarbamoylacetate (172896-57-0) → N-(3-trifluoromethylphenyl)-N-methylthiocarbamoylacetic acid (172896-87-6)

Guidance literature:

With sodium hydroxide; In methanol; water; at 20 ℃;

DOI:10.1080/00397910008087354

Reference yield:

ethyl N-methyl-N-(3-trifluoromethylphenyl)thiocarbamoylacetate (172896-57-0) → N-(3-trifluoromethylphenyl)-N-methylthioacetamide

Guidance literature:

Multi-step reaction with 2 steps

1: 94 percent / NaOH / methanol; H₂O / 20 °C

With sodium hydroxide; In methanol; water; 1: Hydrolysis / 2: Decarboxylation;

DOI:10.1080/00397910008087354

upstream raw materials:

Monothiomalonsaeure-O,O-diethylester

N-methyl-3-(trifluoromethyl)aniline

Downstream raw materials:

N-(3-trifluoromethylphenyl)-N-methylthiocarbamoylacetic acid