2-((R)-3-(bis(2-methoxyphenyl)methylene)-2,2-dimethylcyclopentyl)acetic acid

Base Information

• Chemical Name: 2-((R)-3-(bis(2-methoxyphenyl)methylene)-2,2-dimethylcyclopentyl)acetic acid
• CAS No.: 1420814-33-0
• Molecular Formula: C₂₄H₂₈O₄
• Molecular Weight: 380.484
• Mol file: 1420814-33-0.mol

Synonyms:2-((R)-3-(bis(2-methoxyphenyl)methylene)-2,2-dimethylcyclopentyl)acetic acid

Chemical Property of 2-((R)-3-(bis(2-methoxyphenyl)methylene)-2,2-dimethylcyclopentyl)acetic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-((R)-3-(bis(2-methoxyphenyl)methylene)-2,2-dimethylcyclopentyl)acetic acid

There total 3 articles about 2-((R)-3-(bis(2-methoxyphenyl)methylene)-2,2-dimethylcyclopentyl)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

1-(hydroxybis(2-methoxyphenyl)methyl)-7,7-dimethylbicyclo[2.2.1]heptan-2-one (1420814-20-5) → 2-((R)-3-(bis(2-methoxyphenyl)methylene)-2,2-dimethylcyclopentyl)acetic acid (1420814-33-0)

Guidance literature:

With boron trifluoride diethyl etherate; In toluene; at 80 ℃; for 0.25h; Inert atmosphere;

DOI:10.1016/j.tet.2012.12.011

Reference yield:

(1S)-(+)-ketopinic acid (464-78-8,6994-94-1,64234-14-6,40724-67-2) → 2-((R)-3-(bis(2-methoxyphenyl)methylene)-2,2-dimethylcyclopentyl)acetic acid (1420814-33-0)

Guidance literature:

Multi-step reaction with 3 steps

1.1: thionyl chloride / 22 h / 0 - 20 °C / Inert atmosphere

2.1: magnesium; iodine / tetrahydrofuran / Inert atmosphere; Reflux

2.2: 1 h / 0 °C / Inert atmosphere

3.1: boron trifluoride diethyl etherate / toluene / 0.25 h / 80 °C / Inert atmosphere

With thionyl chloride; boron trifluoride diethyl etherate; iodine; magnesium; In tetrahydrofuran; toluene;

DOI:10.1016/j.tet.2012.12.011

Reference yield:

(1S,4R)-7,7-dimethyl-2-oxobicyclo[2.2.1]heptane-1-carboxylic acid methylester (125637-45-8) → 2-((R)-3-(bis(2-methoxyphenyl)methylene)-2,2-dimethylcyclopentyl)acetic acid (1420814-33-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: magnesium; iodine / tetrahydrofuran / Inert atmosphere; Reflux

1.2: 1 h / 0 °C / Inert atmosphere

2.1: boron trifluoride diethyl etherate / toluene / 0.25 h / 80 °C / Inert atmosphere

With boron trifluoride diethyl etherate; iodine; magnesium; In tetrahydrofuran; toluene;

DOI:10.1016/j.tet.2012.12.011

upstream raw materials:

1-(hydroxybis(2-methoxyphenyl)methyl)-7,7-dimethylbicyclo[2.2.1]heptan-2-one

(1S)-(+)-ketopinic acid

(1S,4R)-7,7-dimethyl-2-oxobicyclo[2.2.1]heptane-1-carboxylic acid methylester