C₁₈⁽¹³⁾C₈H₂₄FNO₃

Base Information

• Chemical Name: C₁₈⁽¹³⁾C₈H₂₄FNO₃
• CAS No.: 222412-76-2
• Molecular Formula: C₂₆H₂₄FNO₃
• Molecular Weight: 425.392
• Mol file: 222412-76-2.mol

Synonyms:C₁₈⁽¹³⁾C₈H₂₄FNO₃

Chemical Property of C₁₈⁽¹³⁾C₈H₂₄FNO₃

Chemical Property:

Purity/Quality:

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Technology Process of C₁₈⁽¹³⁾C₈H₂₄FNO₃

There total 3 articles about C₁₈⁽¹³⁾C₈H₂₄FNO₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 26.0%

4-fluoro[α-13C]benzaldehyde (222412-70-6) + C12(13)C7H19NO2 (222412-74-0) → C18(13)C8H24FNO3 (222412-76-2)

Guidance literature:

With 3-ethyl-5-(2-hydroxyethyl)-4-methyl-1,3-thiazolium bromide; triethylamine; In ethanol; at 60 - 71 ℃;

DOI:10.1002/(SICI)1099-1344(199902)42:2<135::AID-JLCR175>3.0.CO;2-M

Reference yield:

p-Fluorbenzylalkohol-α-13C (73607-91-7) → C18(13)C8H24FNO3 (222412-76-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 850 mg / pyridinium chlorochromate / CH₂Cl₂ / 1.5 h / Heating

2: 26 percent / 3-ethyl-5-(2-hydroxyethyl)-4-methylthiazolium bromide; triethylamine / ethanol / 60 - 71 °C

With 3-ethyl-5-(2-hydroxyethyl)-4-methyl-1,3-thiazolium bromide; triethylamine; pyridinium chlorochromate; In ethanol; dichloromethane; 1: Oxidation / 2: Stetter condensation;

DOI:10.1002/(SICI)1099-1344(199902)42:2<135::AID-JLCR175>3.0.CO;2-M

Reference yield:

4-fluoro[α-13C]benzoic acid (73607-90-6) → C18(13)C8H24FNO3 (222412-76-2)

Guidance literature:

Multi-step reaction with 3 steps

1: BH₃*Me₂S / diethyl ether / 1.25 h / Heating

2: 850 mg / pyridinium chlorochromate / CH₂Cl₂ / 1.5 h / Heating

3: 26 percent / 3-ethyl-5-(2-hydroxyethyl)-4-methylthiazolium bromide; triethylamine / ethanol / 60 - 71 °C

With dimethylsulfide borane complex; 3-ethyl-5-(2-hydroxyethyl)-4-methyl-1,3-thiazolium bromide; triethylamine; pyridinium chlorochromate; In diethyl ether; ethanol; dichloromethane; 1: Reduction / 2: Oxidation / 3: Stetter condensation;

DOI:10.1002/(SICI)1099-1344(199902)42:2<135::AID-JLCR175>3.0.CO;2-M

upstream raw materials:

4-fluoro[α-13C]benzaldehyde

C₁₂⁽¹³⁾C₇H₁₉NO₂

p-Fluorbenzylalkohol-α-¹³C

4-fluoro[α-13C]benzoic acid

Downstream raw materials:

C₃₂⁽¹³⁾C₈H₄₇FN₂O₅