2-tert-butoxycarbonylamino-6-phenethyl-1,2,3,4-tetrahydro-naphthalene-2-carboxylic acid

Base Information

Chemical Name:2-tert-butoxycarbonylamino-6-phenethyl-1,2,3,4-tetrahydro-naphthalene-2-carboxylic acid
CAS No.:936633-48-6
Molecular Formula:C₂₄H₂₉NO₄
Molecular Weight:395.499
Hs Code.:

2-<i>tert</i>-butoxycarbonylamino-6-phenethyl-1,2,3,4-tetrahydro-naphthalene-2-carboxylic acid

Synonyms:2-tert-butoxycarbonylamino-6-phenethyl-1,2,3,4-tetrahydro-naphthalene-2-carboxylic acid

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Chemical Property of 2-tert-butoxycarbonylamino-6-phenethyl-1,2,3,4-tetrahydro-naphthalene-2-carboxylic acid

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Technology Process of 2-tert-butoxycarbonylamino-6-phenethyl-1,2,3,4-tetrahydro-naphthalene-2-carboxylic acid

There total 4 articles about 2-tert-butoxycarbonylamino-6-phenethyl-1,2,3,4-tetrahydro-naphthalene-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 936633-46-4
2-tert-butoxycarbonylamino-6-phenethyl-1,2,3,4-tetrahydro-naphthalene-2-carboxylic acid methyl ester

: 936633-48-6
2-tert-butoxycarbonylamino-6-phenethyl-1,2,3,4-tetrahydro-naphthalene-2-carboxylic acid

Guidance literature:: With lithium hydroxide; In tetrahydrofuran; methanol; water; at 20 ℃;
DOI:10.1021/jm0614073

Reference yield:

: 100-42-5,25038-60-2,25247-68-1,28213-80-1,28325-75-9,79637-11-9,9003-53-6
styrene

: 936633-48-6
2-tert-butoxycarbonylamino-6-phenethyl-1,2,3,4-tetrahydro-naphthalene-2-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 71 percent / cesium carbonate; molecular sieves 4 Angstroem / P(t-Bu)3; Pd₂(dba)3 / dioxane / 18 h / Heating

2: 90 percent / hydrogen / Pd/C / ethyl acetate / 20 °C

3: 90 percent / lithium hydroxide monohydrate / tetrahydrofuran; methanol; H₂O / 20 °C

With lithium hydroxide; 4 A molecular sieve; hydrogen; caesium carbonate; palladium on activated charcoal; tris(dibenzylideneacetone)dipalladium ⁽⁰⁾; tri-tert-butyl phosphine; In tetrahydrofuran; 1,4-dioxane; methanol; water; ethyl acetate;
DOI:10.1021/jm0614073

Reference yield:

: 936633-44-2
2-tert-butoxycarbonylamino-6-styryl-1,2,3,4-tetrahydro-naphthalene-2-carboxylic acid methyl ester

: 936633-48-6
2-tert-butoxycarbonylamino-6-phenethyl-1,2,3,4-tetrahydro-naphthalene-2-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 90 percent / hydrogen / Pd/C / ethyl acetate / 20 °C

2: 90 percent / lithium hydroxide monohydrate / tetrahydrofuran; methanol; H₂O / 20 °C

With lithium hydroxide; hydrogen; palladium on activated charcoal; In tetrahydrofuran; methanol; water; ethyl acetate;
DOI:10.1021/jm0614073