(R)-2-[(7R,8S,9S)-9-((S)-2-Benzenesulfinyl-1-methyl-ethyl)-8-methyl-6,10-dioxa-spiro[4.5]dec-7-yl]-3-methylene-pentan-2-ol

Base Information

Chemical Name:(R)-2-[(7R,8S,9S)-9-((S)-2-Benzenesulfinyl-1-methyl-ethyl)-8-methyl-6,10-dioxa-spiro[4.5]dec-7-yl]-3-methylene-pentan-2-ol
CAS No.:82294-15-3
Molecular Formula:C₂₄H₃₆O₄S
Molecular Weight:420.613
Hs Code.:

Synonyms:(R)-2-[(7R,8S,9S)-9-((S)-2-Benzenesulfinyl-1-methyl-ethyl)-8-methyl-6,10-dioxa-spiro[4.5]dec-7-yl]-3-methylene-pentan-2-ol

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Chemical Property of (R)-2-[(7R,8S,9S)-9-((S)-2-Benzenesulfinyl-1-methyl-ethyl)-8-methyl-6,10-dioxa-spiro[4.5]dec-7-yl]-3-methylene-pentan-2-ol

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Technology Process of (R)-2-[(7R,8S,9S)-9-((S)-2-Benzenesulfinyl-1-methyl-ethyl)-8-methyl-6,10-dioxa-spiro[4.5]dec-7-yl]-3-methylene-pentan-2-ol

There total 11 articles about (R)-2-[(7R,8S,9S)-9-((S)-2-Benzenesulfinyl-1-methyl-ethyl)-8-methyl-6,10-dioxa-spiro[4.5]dec-7-yl]-3-methylene-pentan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 34680-67-6
(1-methylenepropyl)magnesium bromide

: 82281-63-8
1-[(7R,8S,9S)-9-((S)-2-Benzenesulfinyl-1-methyl-ethyl)-8-methyl-6,10-dioxa-spiro[4.5]dec-7-yl]-ethanone

: 82294-15-3
(R)-2-[(7R,8S,9S)-9-((S)-2-Benzenesulfinyl-1-methyl-ethyl)-8-methyl-6,10-dioxa-spiro[4.5]dec-7-yl]-3-methylene-pentan-2-ol

Guidance literature:: In tetrahydrofuran; at -78 ℃;
DOI:10.1021/ja00381a035

Reference yield:

: 82335-28-2
(3S,4R,5R)-4-(tert-Butyl-dimethyl-silanyloxy)-3,5-dimethyl-tetrahydro-pyran-2-one

: 82294-15-3
(R)-2-[(7R,8S,9S)-9-((S)-2-Benzenesulfinyl-1-methyl-ethyl)-8-methyl-6,10-dioxa-spiro[4.5]dec-7-yl]-3-methylene-pentan-2-ol

Guidance literature:: Multi-step reaction with 10 steps

1: Dibal / tetrahydrofuran / -78 °C

2: diethyl ether

3: tetrabutylammonium fluoride / tetrahydrofuran

4: DMAP / CH₂Cl₂; triethylamine

5: pyridinium tosylate / CH₂Cl₂

6: ethanol

7: sodium periodate / H₂O; methanol

8: ozone

9: potassium carbonate / methanol / 4 h

10: 88 percent / tetrahydrofuran / -78 °C

With dmap; sodium periodate; tetrabutyl ammonium fluoride; pyridinium p-toluenesulfonate; diisobutylaluminium hydride; potassium carbonate; ozone; In tetrahydrofuran; methanol; diethyl ether; ethanol; dichloromethane; water; triethylamine;
DOI:10.1021/ja00381a035

Reference yield:

: (8S,9S)-7-Isopropenyl-8-methyl-9-((S)-1-methyl-2-phenylsulfanyl-ethyl)-6,10-dioxa-spiro[4.5]decane

: 82294-15-3
(R)-2-[(7R,8S,9S)-9-((S)-2-Benzenesulfinyl-1-methyl-ethyl)-8-methyl-6,10-dioxa-spiro[4.5]dec-7-yl]-3-methylene-pentan-2-ol

Guidance literature:: Multi-step reaction with 4 steps

1: sodium periodate / H₂O; methanol

2: ozone

3: potassium carbonate / methanol / 4 h

4: 88 percent / tetrahydrofuran / -78 °C

With sodium periodate; potassium carbonate; ozone; In tetrahydrofuran; methanol; water;
DOI:10.1021/ja00381a035