C₂₁H₂₀ClNO₂

Base Information

• Chemical Name: C₂₁H₂₀ClNO₂
• CAS No.: 1090511-06-0
• Molecular Formula: C₂₁H₂₀ClNO₂
• Molecular Weight: 353.848
• Mol file: 1090511-06-0.mol

Synonyms:C₂₁H₂₀ClNO₂

Chemical Property of C₂₁H₂₀ClNO₂

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₁H₂₀ClNO₂

There total 10 articles about C₂₁H₂₀ClNO₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-Bromo-5-chloro-pyridine (40473-01-6) + C16H19BO4 (1090512-27-8) → C21H20ClNO2 (1090511-06-0)

Guidance literature:

With potassium phosphate; sodium 2'‐(dicyclohexylphosphaneyl)‐2,6‐diisopropyl‐[1,1'‐biphenyl]‐3‐sulfonate; palladium diacetate; In water; acetonitrile; at 20 - 160 ℃; for 0.333333h; Microwave irradiation;

Reference yield:

2-ethyl-5-bromoaniline (14922-91-9) → C21H20ClNO2 (1090511-06-0)

Guidance literature:

Multi-step reaction with 7 steps

1.1: sulfuric acid / water / Heating / reflux

1.2: 0.75 h / 0 - 5 °C

1.3: 20 - 80 °C

2.1: isopropylmagnesium chloride / tetrahydrofuran / 1.33 h / -78 - 20 °C

2.2: 2 h / -78 - 20 °C

3.1: mercury(II) diacetate / chloroform / 5 h / 40 °C

4.1: dmap / chloroform / 1.08 h / 20 - 80 °C

5.1: 1,1,1,3,3,3-hexamethyl-disilazane; sodium iodide / trans-N,N'-dimethyl-1,2-cyclohexyldiamine; copper(l) iodide / 1,4-dioxane / 1 h / 180 °C / Microwave irradiation

6.1: TurboGrignard / tetrahydrofuran / 1.67 h / -10 °C

6.2: 1.08 h / -78 - 20 °C

7.1: potassium phosphate / sodium 2'‐(dicyclohexylphosphaneyl)‐2,6‐diisopropyl‐[1,1'‐biphenyl]‐3‐sulfonate; palladium diacetate / water; acetonitrile / 0.33 h / 20 - 160 °C / Microwave irradiation

With dmap; potassium phosphate; TurboGrignard; sulfuric acid; mercury(II) diacetate; isopropylmagnesium chloride; 1,1,1,3,3,3-hexamethyl-disilazane; sodium iodide; sodium 2'‐(dicyclohexylphosphaneyl)‐2,6‐diisopropyl‐[1,1'‐biphenyl]‐3‐sulfonate; trans-N,N'-dimethyl-1,2-cyclohexyldiamine; palladium diacetate; copper(l) iodide; In tetrahydrofuran; 1,4-dioxane; chloroform; water; acetonitrile; 7.1: Suzuki-Miyaura reaction;

Reference yield:

4-bromo-1-ethyl-2-iodobenzene (1033760-94-9) → C21H20ClNO2 (1090511-06-0)

Guidance literature:

Multi-step reaction with 6 steps

1.1: isopropylmagnesium chloride / tetrahydrofuran / 1.33 h / -78 - 20 °C

1.2: 2 h / -78 - 20 °C

2.1: mercury(II) diacetate / chloroform / 5 h / 40 °C

3.1: dmap / chloroform / 1.08 h / 20 - 80 °C

4.1: 1,1,1,3,3,3-hexamethyl-disilazane; sodium iodide / trans-N,N'-dimethyl-1,2-cyclohexyldiamine; copper(l) iodide / 1,4-dioxane / 1 h / 180 °C / Microwave irradiation

5.1: TurboGrignard / tetrahydrofuran / 1.67 h / -10 °C

5.2: 1.08 h / -78 - 20 °C

6.1: potassium phosphate / sodium 2'‐(dicyclohexylphosphaneyl)‐2,6‐diisopropyl‐[1,1'‐biphenyl]‐3‐sulfonate; palladium diacetate / water; acetonitrile / 0.33 h / 20 - 160 °C / Microwave irradiation

With dmap; potassium phosphate; TurboGrignard; mercury(II) diacetate; isopropylmagnesium chloride; 1,1,1,3,3,3-hexamethyl-disilazane; sodium iodide; sodium 2'‐(dicyclohexylphosphaneyl)‐2,6‐diisopropyl‐[1,1'‐biphenyl]‐3‐sulfonate; trans-N,N'-dimethyl-1,2-cyclohexyldiamine; palladium diacetate; copper(l) iodide; In tetrahydrofuran; 1,4-dioxane; chloroform; water; acetonitrile; 6.1: Suzuki-Miyaura reaction;

upstream raw materials:

2-Bromo-5-chloro-pyridine

C₁₆H₁₉BO₄

2-ethyl-5-bromoaniline

4-bromo-1-ethyl-2-iodobenzene