1-methyl-5-(3-trifluoromethylphenyl)pyrrole-2-carboxylic acid benzylamide

Base Information

Chemical Name:1-methyl-5-(3-trifluoromethylphenyl)pyrrole-2-carboxylic acid benzylamide
CAS No.:1330033-81-2
Molecular Formula:C₂₀H₁₇F₃N₂O
Molecular Weight:358.363
Hs Code.:

Synonyms:1-methyl-5-(3-trifluoromethylphenyl)pyrrole-2-carboxylic acid benzylamide

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Chemical Property of 1-methyl-5-(3-trifluoromethylphenyl)pyrrole-2-carboxylic acid benzylamide

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Technology Process of 1-methyl-5-(3-trifluoromethylphenyl)pyrrole-2-carboxylic acid benzylamide

There total 3 articles about 1-methyl-5-(3-trifluoromethylphenyl)pyrrole-2-carboxylic acid benzylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 401-78-5
3-bromo-1-trifluoromethylbenzene

: 504434-04-2
1-methylpyrrole-2-carboxylic acid benzylamide

: 1330033-81-2
1-methyl-5-(3-trifluoromethylphenyl)pyrrole-2-carboxylic acid benzylamide

Guidance literature:: With Pd(C₃H₅)Cl(dppb); potassium acetate; In N,N-dimethyl acetamide; at 150 ℃; for 16h; regioselective reaction; Inert atmosphere;
DOI:10.1002/ejoc.201100312

Reference yield:

: 26214-68-6
1-methyl-pyrrole-2-carboxylic acid chloride

: 1330033-81-2
1-methyl-5-(3-trifluoromethylphenyl)pyrrole-2-carboxylic acid benzylamide

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 3 h / 20 °C

2: Pd(C₃H₅)Cl(dppb); potassium acetate / N,N-dimethyl acetamide / 16 h / 150 °C / Inert atmosphere

With Pd(C₃H₅)Cl(dppb); potassium acetate; triethylamine; In dichloromethane; N,N-dimethyl acetamide;
DOI:10.1002/ejoc.201100312

Reference yield:

: 100-46-9
benzylamine

: 1330033-81-2
1-methyl-5-(3-trifluoromethylphenyl)pyrrole-2-carboxylic acid benzylamide

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 3 h / 20 °C

2: Pd(C₃H₅)Cl(dppb); potassium acetate / N,N-dimethyl acetamide / 16 h / 150 °C / Inert atmosphere

With Pd(C₃H₅)Cl(dppb); potassium acetate; triethylamine; In dichloromethane; N,N-dimethyl acetamide;
DOI:10.1002/ejoc.201100312