6,7-dimethoxy-3-(2-nitroethenyl)indole

Base Information

Chemical Name:6,7-dimethoxy-3-(2-nitroethenyl)indole
CAS No.:322765-37-7
Molecular Formula:C₁₂H₁₂N₂O₄
Molecular Weight:248.238
Hs Code.:

Synonyms:6,7-dimethoxy-3-(2-nitroethenyl)indole

Suppliers and Price of 6,7-dimethoxy-3-(2-nitroethenyl)indole

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 6,7-dimethoxy-3-(2-nitroethenyl)indole

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 6,7-dimethoxy-3-(2-nitroethenyl)indole

There total 1 articles about 6,7-dimethoxy-3-(2-nitroethenyl)indole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 55149-84-3
2-nitroveratraldehyde

: 322765-37-7
6,7-dimethoxy-3-(2-nitroethenyl)indole

Guidance literature:: Multi-step reaction with 4 steps

1.1: KOH / dimethylformamide; ethanol

1.2: 73 percent / Ac₂O; NaOAc / Heating

2.1: 85 percent / Fe / acetic acid; ethanol / 95 °C

3.1: 92 percent / POCl₃ / 0 - 25 °C

4.1: 100 percent / NH₄OAc / 0.67 h / Heating

With potassium hydroxide; ammonium acetate; iron; trichlorophosphate; In ethanol; acetic acid; N,N-dimethyl-formamide; 1.1: Henry reaction / 3.1: Vilsmeier formylation / 4.1: Henry reaction;
DOI:10.1016/S0040-4020(02)00243-0

Reference yield:

: 322765-37-7
6,7-dimethoxy-3-(2-nitroethenyl)indole

: 322765-43-5
(+/-)-5,8,9,10,11,14-hexahydro-6H-15,16-dimethoxy-7,14-diazacycloundeca[a]indene-7,13-dimethoxy-7,14-diazacycloundeca[a]indene-7,13-dicarboxylic acid 13-methyl ester 7-phenyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 91 percent / LiAlH₄ / tetrahydrofuran / 1 h / Heating

2: 2.0 g / molecular sieves 4 Angstroem; trifluoroacetic acid / CH₂Cl₂ / 0 - 23 °C

3: 67 percent / 1-hydroxybenzotriazole monohydrate; EDCI; Et₃N / dimethylformamide / 25 h / 0 - 20 °C

4: 100 percent / Bellau's reagent / tetrahydrofuran / 15 h / 0 - 23 °C

5: 77 percent / NiCl₂*6H₂O; NaBH₄ / tetrahydrofuran; methanol / 0.08 h / 0 °C

6: 47 percent / CH₂Cl₂ / 48 h / Heating

With sodium tetrahydroborate; lithium aluminium tetrahydride; 4 A molecular sieve; 2,4-(4-phenoxyphenyl)-1,3-dithia-2λ(5),4λ(5)-diphosphetane 2,4-disulfides; 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid; nickel dichloride; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; 2: Pictet Spengler reaction;
DOI:10.1016/S0040-4020(02)00243-0

Reference yield:

: 322765-37-7
6,7-dimethoxy-3-(2-nitroethenyl)indole

: 1,2-dimethoxy-5,7,8,9,10,13-hexahydro-6,13-diaza-cyclodeca[a]indene-6,12-dicarboxylic acid 12-methyl ester 6-phenyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 91 percent / LiAlH₄ / tetrahydrofuran / Heating

2: CF₃CO₂H; 4 Angstroem molecular sieves / CH₂Cl₂ / 0 - 23 °C

3: EDCI; HOBt; Et₃N / dimethylformamide / 0 - 23 °C

4: 100 percent / Belleau's reagent / tetrahydrofuran / 0 - 23 °C

5: 77 percent / NiCl₂*6H₂O; NaBH₄ / tetrahydrofuran; methanol / 0 °C

6: 47 percent / 1,2-dichloro-ethane / 48 h / Heating

With sodium tetrahydroborate; lithium aluminium tetrahydride; 4 A molecular sieve; benzotriazol-1-ol; 2,4-(4-phenoxyphenyl)-1,3-dithia-2λ(5),4λ(5)-diphosphetane 2,4-disulfides; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid; nickel dichloride; In tetrahydrofuran; methanol; dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide; 1: Reduction / 2: Pictet-Spengler reaction / 3: Cyclization / 4: sulfuration / 5: Reduction / 6: Acylation;
DOI:10.1016/S0040-4039(00)01399-X