(E)-4-(3-benzoyl-1H-pyrrol-1-yl)-2-hydroxybenzaldoxime

Base Information

• Chemical Name: (E)-4-(3-benzoyl-1H-pyrrol-1-yl)-2-hydroxybenzaldoxime
• CAS No.: 1594782-10-1
• Molecular Formula: C₁₈H₁₄N₂O₃
• Molecular Weight: 306.321
• Mol file: 1594782-10-1.mol

Synonyms:(E)-4-(3-benzoyl-1H-pyrrol-1-yl)-2-hydroxybenzaldoxime

Chemical Property of (E)-4-(3-benzoyl-1H-pyrrol-1-yl)-2-hydroxybenzaldoxime

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E)-4-(3-benzoyl-1H-pyrrol-1-yl)-2-hydroxybenzaldoxime

There total 4 articles about (E)-4-(3-benzoyl-1H-pyrrol-1-yl)-2-hydroxybenzaldoxime which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

4-(3-benzoyl-1H-pyrrol-1-yl)-2-hydroxybenzaldehyde (1594782-03-2) → (E)-4-(3-benzoyl-1H-pyrrol-1-yl)-2-hydroxybenzaldoxime (1594782-10-1)

Guidance literature:

With hydroxylamine hydrochloride; In ethanol; water; at 50 ℃; for 1h; Inert atmosphere;

DOI:10.1016/j.bmc.2014.02.016

Reference yield:

C24H17NO3 → (E)-4-(3-benzoyl-1H-pyrrol-1-yl)-2-hydroxybenzaldoxime (1594782-10-1)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium hydroxide; water / 1,4-dioxane / 20 °C / Inert atmosphere

2: magnesium chloride; triethylamine; sodium; phosphorus pentoxide; calcium hydride / acetonitrile / 72 h / Reflux; Inert atmosphere; Molecular sieve

3: hydroxylamine hydrochloride / water; ethanol / 1 h / 50 °C / Inert atmosphere

With calcium hydride; phosphorus pentoxide; hydroxylamine hydrochloride; water; sodium; triethylamine; sodium hydroxide; magnesium chloride; In 1,4-dioxane; ethanol; water; acetonitrile;

DOI:10.1016/j.bmc.2014.02.016

Reference yield:

3-(1H-pyrrol-1-yl)phenol (137352-78-4) → (E)-4-(3-benzoyl-1H-pyrrol-1-yl)-2-hydroxybenzaldoxime (1594782-10-1)

Guidance literature:

Multi-step reaction with 4 steps

1.1: aluminum (III) chloride / 1,2-dichloro-ethane / 0.25 h / 20 °C / Inert atmosphere

1.2: 48 h / 20 °C / Inert atmosphere

2.1: sodium hydroxide; water / 1,4-dioxane / 20 °C / Inert atmosphere

3.1: magnesium chloride; triethylamine; sodium; phosphorus pentoxide; calcium hydride / acetonitrile / 72 h / Reflux; Inert atmosphere; Molecular sieve

4.1: hydroxylamine hydrochloride / water; ethanol / 1 h / 50 °C / Inert atmosphere

With aluminum (III) chloride; calcium hydride; phosphorus pentoxide; hydroxylamine hydrochloride; water; sodium; triethylamine; sodium hydroxide; magnesium chloride; In 1,4-dioxane; ethanol; water; 1,2-dichloro-ethane; acetonitrile; 1.1: |Friedel-Crafts Acylation / 1.2: |Friedel-Crafts Acylation;

DOI:10.1016/j.bmc.2014.02.016

upstream raw materials:

[1-(3-hydroxyphenyl)-1H-pyrrol-3-yl]phenylmethanone

4-(3-benzoyl-1H-pyrrol-1-yl)-2-hydroxybenzaldehyde

3-(1H-pyrrol-1-yl)phenol