2-[(S)-2-(tert-Butyl-dimethyl-silanyloxy)-3-tritylsulfanyl-propyl]-nonanoic acid ((S)-2,2-dimethyl-1-methylcarbamoyl-propyl)-amide

Base Information

Chemical Name:2-[(S)-2-(tert-Butyl-dimethyl-silanyloxy)-3-tritylsulfanyl-propyl]-nonanoic acid ((S)-2,2-dimethyl-1-methylcarbamoyl-propyl)-amide
CAS No.:249588-55-4
Molecular Formula:C₄₄H₆₆N₂O₃SSi
Molecular Weight:731.171
Hs Code.:

Synonyms:2-[(S)-2-(tert-Butyl-dimethyl-silanyloxy)-3-tritylsulfanyl-propyl]-nonanoic acid ((S)-2,2-dimethyl-1-methylcarbamoyl-propyl)-amide

Suppliers and Price of 2-[(S)-2-(tert-Butyl-dimethyl-silanyloxy)-3-tritylsulfanyl-propyl]-nonanoic acid ((S)-2,2-dimethyl-1-methylcarbamoyl-propyl)-amide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 2-[(S)-2-(tert-Butyl-dimethyl-silanyloxy)-3-tritylsulfanyl-propyl]-nonanoic acid ((S)-2,2-dimethyl-1-methylcarbamoyl-propyl)-amide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 2-[(S)-2-(tert-Butyl-dimethyl-silanyloxy)-3-tritylsulfanyl-propyl]-nonanoic acid ((S)-2,2-dimethyl-1-methylcarbamoyl-propyl)-amide

There total 7 articles about 2-[(S)-2-(tert-Butyl-dimethyl-silanyloxy)-3-tritylsulfanyl-propyl]-nonanoic acid ((S)-2,2-dimethyl-1-methylcarbamoyl-propyl)-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 89226-12-0
(S)-2-amino-N,3,3-trimethylbutanamide

: 249588-53-2
2-[2-(tert-butyl-dimethyl-silanyloxy)-3-tritylsulfanyl-propyl]-nonanoic acid

: 249588-55-4
2-[(S)-2-(tert-Butyl-dimethyl-silanyloxy)-3-tritylsulfanyl-propyl]-nonanoic acid ((S)-2,2-dimethyl-1-methylcarbamoyl-propyl)-amide

Guidance literature:: With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 12h;
DOI:10.1055/s-1999-2858

Reference yield:

: 3695-77-0
triphenylmethanethiol

: 249588-55-4
2-[(S)-2-(tert-Butyl-dimethyl-silanyloxy)-3-tritylsulfanyl-propyl]-nonanoic acid ((S)-2,2-dimethyl-1-methylcarbamoyl-propyl)-amide

Guidance literature:: Multi-step reaction with 7 steps

1.1: 63 percent / KF / methanol / 36 h / 20 °C

2.1: 88 percent / imidazole; DMAP / CH₂Cl₂ / 12 h / 20 °C

3.1: NaH / dimethylformamide / 1 h / 20 °C

3.2: 53 percent / TBAI; imidazole / dimethylformamide / 18 h / 80 °C

4.1: NaH / dimethylformamide / 0.5 h / 20 °C

4.2: 91 percent / KI / dimethylformamide / 12 h / 50 °C

5.1: morpholine / (Ph₃P)4Pd / tetrahydrofuran / 3 h / 20 °C

6.1: dioxane / 3 h / Heating

7.1: 90 percent / EDC; HOBt; DIEA / CH₂Cl₂ / 12 h / 20 °C

With morpholine; 1H-imidazole; dmap; potassium fluoride; sodium hydride; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide; 1.1: Substitution / 2.1: Substitution / 3.1: Metallation / 3.2: Alkylation / 4.1: Metallation / 4.2: Alkylation / 5.1: Substitution / 6.1: Decarboxylation / 7.1: Acylation;
DOI:10.1055/s-1999-2858

Reference yield:

: 249588-46-3
Toluene-4-sulfonic acid (S)-2-hydroxy-3-tritylsulfanyl-propyl ester

: 249588-55-4
2-[(S)-2-(tert-Butyl-dimethyl-silanyloxy)-3-tritylsulfanyl-propyl]-nonanoic acid ((S)-2,2-dimethyl-1-methylcarbamoyl-propyl)-amide

Guidance literature:: Multi-step reaction with 6 steps

1.1: 88 percent / imidazole; DMAP / CH₂Cl₂ / 12 h / 20 °C

2.1: NaH / dimethylformamide / 1 h / 20 °C

2.2: 53 percent / TBAI; imidazole / dimethylformamide / 18 h / 80 °C

3.1: NaH / dimethylformamide / 0.5 h / 20 °C

3.2: 91 percent / KI / dimethylformamide / 12 h / 50 °C

4.1: morpholine / (Ph₃P)4Pd / tetrahydrofuran / 3 h / 20 °C

5.1: dioxane / 3 h / Heating

6.1: 90 percent / EDC; HOBt; DIEA / CH₂Cl₂ / 12 h / 20 °C

With morpholine; 1H-imidazole; dmap; sodium hydride; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide; 1.1: Substitution / 2.1: Metallation / 2.2: Alkylation / 3.1: Metallation / 3.2: Alkylation / 4.1: Substitution / 5.1: Decarboxylation / 6.1: Acylation;
DOI:10.1055/s-1999-2858