2-((2-((1R,1'R,3r,3'R,5S,5'S)-[3,9'-bi(9'-azabicyclo[3.3.1]nonan)]-3'-ylamino)phenyl)amino)-2-oxoethyl acetate

Base Information

Chemical Name:2-((2-((1R,1'R,3r,3'R,5S,5'S)-[3,9'-bi(9'-azabicyclo[3.3.1]nonan)]-3'-ylamino)phenyl)amino)-2-oxoethyl acetate
CAS No.:1616764-56-7
Molecular Formula:C₂₇H₃₉N₃O₃
Molecular Weight:453.625
Hs Code.:

Synonyms:2-((2-((1R,1'R,3r,3'R,5S,5'S)-[3,9'-bi(9'-azabicyclo[3.3.1]nonan)]-3'-ylamino)phenyl)amino)-2-oxoethyl acetate

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Chemical Property of 2-((2-((1R,1'R,3r,3'R,5S,5'S)-[3,9'-bi(9'-azabicyclo[3.3.1]nonan)]-3'-ylamino)phenyl)amino)-2-oxoethyl acetate

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Technology Process of 2-((2-((1R,1'R,3r,3'R,5S,5'S)-[3,9'-bi(9'-azabicyclo[3.3.1]nonan)]-3'-ylamino)phenyl)amino)-2-oxoethyl acetate

There total 5 articles about 2-((2-((1R,1'R,3r,3'R,5S,5'S)-[3,9'-bi(9'-azabicyclo[3.3.1]nonan)]-3'-ylamino)phenyl)amino)-2-oxoethyl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.5%

: 1126795-15-0
N₁-((1R,1'R,3R,3'R,5S,5'S)-[3,9'-bi(9'-azabicyclo[3.3.1]nonan)]-3'-yl)benzene-1,2-diamine

: 13831-31-7
Acetoxyacetyl chloride

: 1616764-56-7
2-((2-((1R,1'R,3r,3'R,5S,5'S)-[3,9'-bi(9'-azabicyclo[3.3.1]nonan)]-3'-ylamino)phenyl)amino)-2-oxoethyl acetate

Guidance literature:: In dichloromethane; for 0.5h; Cooling with ice;

Reference yield:

: 1384190-01-5
(1R,1'R,3R,3'R,5S,5'S)-9'-aza[3,9'-bi(bicyclo[3.3.1]nonan)]-3'-amine acetate

: 1616764-56-7
2-((2-((1R,1'R,3r,3'R,5S,5'S)-[3,9'-bi(9'-azabicyclo[3.3.1]nonan)]-3'-ylamino)phenyl)amino)-2-oxoethyl acetate

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 110 °C

2: hydrogen; palladium 10% on activated carbon / methanol / 3 h / 25 °C / 2585.81 Torr

3: dichloromethane / 0.5 h / Cooling with ice

With palladium 10% on activated carbon; hydrogen; potassium carbonate; In methanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: (1R,1'R,3r,5S,5'S)-9'-aza[3,9′-bi(bicyclo[3.3.1]nonan)]-3'-one

: 1616764-56-7
2-((2-((1R,1'R,3r,3'R,5S,5'S)-[3,9'-bi(9'-azabicyclo[3.3.1]nonan)]-3'-ylamino)phenyl)amino)-2-oxoethyl acetate

Guidance literature:: Multi-step reaction with 5 steps

1: acetic acid; hydroxylamine / tetrahydrofuran; water / 17 h / 18 °C / Reflux

2: hydrogen; platinum(IV) oxide / tetrahydrofuran / 25858.1 Torr

3: potassium carbonate / N,N-dimethyl-formamide / 2 h / 110 °C

4: hydrogen; palladium 10% on activated carbon / methanol / 3 h / 25 °C / 2585.81 Torr

5: dichloromethane / 0.5 h / Cooling with ice

With platinum(IV) oxide; palladium 10% on activated carbon; hydrogen; hydroxylamine; potassium carbonate; acetic acid; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide;