pentafluorophenyl 3-(1-methyl-2-oxo-3-trityl-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)benzoate

Base Information

Chemical Name:pentafluorophenyl 3-(1-methyl-2-oxo-3-trityl-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)benzoate
CAS No.:1355152-97-4
Molecular Formula:C₃₉H₂₄F₅N₃O₃
Molecular Weight:677.63
Hs Code.:

Synonyms:pentafluorophenyl 3-(1-methyl-2-oxo-3-trityl-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)benzoate

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Chemical Property of pentafluorophenyl 3-(1-methyl-2-oxo-3-trityl-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)benzoate

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Technology Process of pentafluorophenyl 3-(1-methyl-2-oxo-3-trityl-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)benzoate

There total 5 articles about pentafluorophenyl 3-(1-methyl-2-oxo-3-trityl-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 14533-84-7
pentafluorophenyl trifloroacetate

: 1355152-95-2
3-(1-methyl-2-oxo-3-trityl-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)benzoic acid

: 1355152-97-4
pentafluorophenyl 3-(1-methyl-2-oxo-3-trityl-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)benzoate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 - 20 ℃; for 1.16667h;
DOI:10.1021/jm201349f

Reference yield:

: 6-bromo-3-methyl-2,3-dihydro-1H-imidazo[4,5-b]pyridin-2-one

: 1355152-97-4
pentafluorophenyl 3-(1-methyl-2-oxo-3-trityl-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)benzoate

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / dichloromethane / 16 h / 20 °C

2: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; potassium phosphate; tricyclohexylphosphine / 1,4-dioxane / 1 h / 100 °C / Microwave irradiation

3: N-ethyl-N,N-diisopropylamine / dichloromethane / 1.17 h / 0 - 20 °C

With potassium phosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; triethylamine; N-ethyl-N,N-diisopropylamine; tricyclohexylphosphine; In 1,4-dioxane; dichloromethane;
DOI:10.1021/jm201349f

Reference yield:

: 1355152-77-0
6-bromo-1-methyl-3-trityl-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one

: 1355152-97-4
pentafluorophenyl 3-(1-methyl-2-oxo-3-trityl-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)benzoate

Guidance literature:: Multi-step reaction with 2 steps

1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; potassium phosphate; tricyclohexylphosphine / 1,4-dioxane / 1 h / 100 °C / Microwave irradiation

2: N-ethyl-N,N-diisopropylamine / dichloromethane / 1.17 h / 0 - 20 °C

With potassium phosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; N-ethyl-N,N-diisopropylamine; tricyclohexylphosphine; In 1,4-dioxane; dichloromethane;
DOI:10.1021/jm201349f