N-(((6S,7R)-7-(3,4-dichlorophenyl)-1,4-oxazepan-6-yl)methyl)-2-methoxyacetamide hydrochloride

Base Information

• Chemical Name: N-(((6S,7R)-7-(3,4-dichlorophenyl)-1,4-oxazepan-6-yl)methyl)-2-methoxyacetamide hydrochloride
• CAS No.: 1372179-95-7
• Molecular Formula: C₁₅H₂₀Cl₂N₂O₃*ClH
• Molecular Weight: 383.702
• Mol file: 1372179-95-7.mol

Synonyms:N-(((6S,7R)-7-(3,4-dichlorophenyl)-1,4-oxazepan-6-yl)methyl)-2-methoxyacetamide hydrochloride

Chemical Property of N-(((6S,7R)-7-(3,4-dichlorophenyl)-1,4-oxazepan-6-yl)methyl)-2-methoxyacetamide hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(((6S,7R)-7-(3,4-dichlorophenyl)-1,4-oxazepan-6-yl)methyl)-2-methoxyacetamide hydrochloride

There total 12 articles about N-(((6S,7R)-7-(3,4-dichlorophenyl)-1,4-oxazepan-6-yl)methyl)-2-methoxyacetamide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

(6R,7R)-tert-butyl 7-(3,4-dichlorophenyl)-6-((2-methoxyacetamido)methyl)-1,4-oxazepane-4-carboxylate (1372186-98-5) → N-(((6S,7R)-7-(3,4-dichlorophenyl)-1,4-oxazepan-6-yl)methyl)-2-methoxyacetamide hydrochloride (1372179-95-7)

Guidance literature:

With hydrogenchloride; In ethanol; at 20 ℃; for 1h;

DOI:10.1016/j.bmc.2016.05.038

Reference yield:

tert-butyl (6S,7R)-6-(azidomethyl)-7-(3,4-dichlorophenyl)-1,4-oxazepane-4-carboxylate (1372186-95-2) → N-(((6S,7R)-7-(3,4-dichlorophenyl)-1,4-oxazepan-6-yl)methyl)-2-methoxyacetamide hydrochloride (1372179-95-7)

Guidance literature:

Multi-step reaction with 3 steps

1: triphenylphosphine; water / tetrahydrofuran / 10 - 35 °C

2: triethylamine / tetrahydrofuran / 1 h / 10 - 35 °C

3: hydrogenchloride / ethanol / 1 h / 10 - 35 °C

With hydrogenchloride; water; triethylamine; triphenylphosphine; In tetrahydrofuran; ethanol; 1: Staudinger Reaction;

Reference yield:

tert-butyl (6S,7R)-7-(3,4-dichlorophenyl)-6-(hydroxymethyl)-1,4-oxazepane-4-carboxylate (1372189-39-3) → N-(((6S,7R)-7-(3,4-dichlorophenyl)-1,4-oxazepan-6-yl)methyl)-2-methoxyacetamide hydrochloride (1372179-95-7)

Guidance literature:

Multi-step reaction with 5 steps

1: triethylamine / tetrahydrofuran / 2 h / Cooling with ice

2: sodium azide / N,N-dimethyl-formamide / 70 °C

3: triphenylphosphine; water / tetrahydrofuran / 10 - 35 °C

4: triethylamine / tetrahydrofuran / 1 h / 10 - 35 °C

5: hydrogenchloride / ethanol / 1 h / 10 - 35 °C

With hydrogenchloride; sodium azide; water; triethylamine; triphenylphosphine; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide; 3: Staudinger Reaction;

upstream raw materials:

tert-butyl (6S,7R)-7-(3,4-dichlorophenyl)-6-(hydroxymethyl)-1,4-oxazepane-4-carboxylate

tert-butyl (6S,7R)-7-(3,4-dichlorophenyl)-6-{[(methylsulfonyl)oxy]methyl}-1,4-oxazepane-4-carboxylate

tert-butyl (6S,7R)-6-(azidomethyl)-7-(3,4-dichlorophenyl)-1,4-oxazepane-4-carboxylate

tert-butyl (6R,7R)-6-(aminomethyl)-7-(3,4-dichlorophenyl)-1,4-oxazepane-4-carboxylate