3-[(2R,3R,4R,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-[(5-chloro-quinolin-8-yloxy)-hydroxy-phosphoryloxy]-3-(1-methoxy-1-methyl-ethoxy)-tetrahydro-furan-2-yl]-2,6-dioxo-3,6-dihydro-2H-pyrimidine-1-carbothioic acid S-butyl ester; compound with triethyl-amine

Base Information

Chemical Name:3-[(2R,3R,4R,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-[(5-chloro-quinolin-8-yloxy)-hydroxy-phosphoryloxy]-3-(1-methoxy-1-methyl-ethoxy)-tetrahydro-furan-2-yl]-2,6-dioxo-3,6-dihydro-2H-pyrimidine-1-carbothioic acid S-butyl ester; compound with triethyl-amine
CAS No.:114871-43-1
Molecular Formula:C₆H₁₅N*C₄₈H₅₁ClN₃O₁₃PS
Molecular Weight:1077.63
Hs Code.:

3-[(2R,3R,4R,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-[(5-chloro-quinolin-8-yloxy)-hydroxy-phosphoryloxy]-3-(1-methoxy-1-methyl-ethoxy)-tetrahydro-furan-2-yl]-2,6-dioxo-3,6-dihydro-2H-pyrimidine-1-carbothioic acid S-butyl ester; compound with triethyl-amine

Synonyms:3-[(2R,3R,4R,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-[(5-chloro-quinolin-8-yloxy)-hydroxy-phosphoryloxy]-3-(1-methoxy-1-methyl-ethoxy)-tetrahydro-furan-2-yl]-2,6-dioxo-3,6-dihydro-2H-pyrimidine-1-carbothioic acid S-butyl ester; compound with triethyl-amine

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Chemical Property of 3-[(2R,3R,4R,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-[(5-chloro-quinolin-8-yloxy)-hydroxy-phosphoryloxy]-3-(1-methoxy-1-methyl-ethoxy)-tetrahydro-furan-2-yl]-2,6-dioxo-3,6-dihydro-2H-pyrimidine-1-carbothioic acid S-butyl ester; compound with triethyl-amine

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Technology Process of 3-[(2R,3R,4R,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-[(5-chloro-quinolin-8-yloxy)-hydroxy-phosphoryloxy]-3-(1-methoxy-1-methyl-ethoxy)-tetrahydro-furan-2-yl]-2,6-dioxo-3,6-dihydro-2H-pyrimidine-1-carbothioic acid S-butyl ester; compound with triethyl-amine

There total 6 articles about 3-[(2R,3R,4R,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-[(5-chloro-quinolin-8-yloxy)-hydroxy-phosphoryloxy]-3-(1-methoxy-1-methyl-ethoxy)-tetrahydro-furan-2-yl]-2,6-dioxo-3,6-dihydro-2H-pyrimidine-1-carbothioic acid S-butyl ester; compound with triethyl-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 71933-71-6
O-8-(5-chloroquinolyl) phosphate

: 114871-40-8
3-[(2R,3R,4R,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-3-(1-methoxy-1-methyl-ethoxy)-tetrahydro-furan-2-yl]-2,6-dioxo-3,6-dihydro-2H-pyrimidine-1-carbothioic acid S-butyl ester

: 121-44-8
triethylamine

: 114871-43-1
3-[(2R,3R,4R,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-[(5-chloro-quinolin-8-yloxy)-hydroxy-phosphoryloxy]-3-(1-methoxy-1-methyl-ethoxy)-tetrahydro-furan-2-yl]-2,6-dioxo-3,6-dihydro-2H-pyrimidine-1-carbothioic acid S-butyl ester; compound with triethyl-amine

Guidance literature:: With quinoline-8-sulfonyl chloride; In pyridine; for 2h;
DOI:10.1246/cl.1987.1787

Reference yield:

: 13889-94-6
butyl chlorothioformate

: 114871-43-1
3-[(2R,3R,4R,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-[(5-chloro-quinolin-8-yloxy)-hydroxy-phosphoryloxy]-3-(1-methoxy-1-methyl-ethoxy)-tetrahydro-furan-2-yl]-2,6-dioxo-3,6-dihydro-2H-pyrimidine-1-carbothioic acid S-butyl ester; compound with triethyl-amine

Guidance literature:: Multi-step reaction with 4 steps

1: i-Pr₂NEt / pyridine / 24 h

2: TBAF / tetrahydrofuran

3: pyridine

4: 87 percent / 8-quinolinesulfonyl chloride / pyridine / 2 h

With pyridine; quinoline-8-sulfonyl chloride; tetrabutyl ammonium fluoride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; pyridine;
DOI:10.1246/cl.1987.1787

Reference yield:

: 114871-32-8
3-[(2R,3R,4R,5R)-4-Hydroxy-5-hydroxymethyl-3-(1-methoxy-1-methyl-ethoxy)-tetrahydro-furan-2-yl]-2,6-dioxo-3,6-dihydro-2H-pyrimidine-1-carbothioic acid S-butyl ester

: 114871-43-1
3-[(2R,3R,4R,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-[(5-chloro-quinolin-8-yloxy)-hydroxy-phosphoryloxy]-3-(1-methoxy-1-methyl-ethoxy)-tetrahydro-furan-2-yl]-2,6-dioxo-3,6-dihydro-2H-pyrimidine-1-carbothioic acid S-butyl ester; compound with triethyl-amine

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine

2: 87 percent / 8-quinolinesulfonyl chloride / pyridine / 2 h

With pyridine; quinoline-8-sulfonyl chloride; In pyridine;
DOI:10.1246/cl.1987.1787