N-{(2R,3R)-1-[difluoro(phenylseleno)methyl]-2,3-dihydroxypent-4-yn-1-yl}-2-methylpropane-2-sulfinamide

Base Information

• Chemical Name: N-{(2R,3R)-1-[difluoro(phenylseleno)methyl]-2,3-dihydroxypent-4-yn-1-yl}-2-methylpropane-2-sulfinamide
• CAS No.: 1359718-19-6
• Molecular Formula: C₁₆H₂₁F₂NO₃SSe
• Molecular Weight: 424.37

Synonyms:N-{(2R,3R)-1-[difluoro(phenylseleno)methyl]-2,3-dihydroxypent-4-yn-1-yl}-2-methylpropane-2-sulfinamide

Chemical Property of N-{(2R,3R)-1-[difluoro(phenylseleno)methyl]-2,3-dihydroxypent-4-yn-1-yl}-2-methylpropane-2-sulfinamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-{(2R,3R)-1-[difluoro(phenylseleno)methyl]-2,3-dihydroxypent-4-yn-1-yl}-2-methylpropane-2-sulfinamide

There total 6 articles about N-{(2R,3R)-1-[difluoro(phenylseleno)methyl]-2,3-dihydroxypent-4-yn-1-yl}-2-methylpropane-2-sulfinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

C19H29F2NO3SSeSi (1359718-21-0) → N-{(2R,3R)-1-[difluoro(phenylseleno)methyl]-2,3-dihydroxypent-4-yn-1-yl}-2-methylpropane-2-sulfinamide (1359718-19-6)

Guidance literature:

With potassium carbonate; In methanol; at 20 ℃; for 1h; Inert atmosphere;

DOI:10.1016/j.jfluchem.2011.02.015

Reference yield:

1,2-Dideoxy-3,4-O-(1-methylethylidene)-D-threo-pent-1-ynitol (320396-46-1) → N-{(2R,3R)-1-[difluoro(phenylseleno)methyl]-2,3-dihydroxypent-4-yn-1-yl}-2-methylpropane-2-sulfinamide (1359718-19-6)

Guidance literature:

Multi-step reaction with 5 steps

1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / ethyl acetate / 7 h / Reflux; Inert atmosphere

2: titanium(IV) tetraethanolate / tetrahydrofuran / 1 h / Inert atmosphere; Reflux

3: tetrabutylammonium triphenyldifluorosilicate / N,N-dimethyl-formamide / 2 h / -60 °C / Molecular sieve; Inert atmosphere

4: trifluoroacetic acid / water / 3 h / 20 °C / Inert atmosphere

5: potassium carbonate / methanol / 1 h / 20 °C / Inert atmosphere

With titanium(IV) tetraethanolate; potassium carbonate; tetrabutylammonium triphenyldifluorosilicate; trifluoroacetic acid; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In tetrahydrofuran; methanol; water; ethyl acetate; N,N-dimethyl-formamide;

DOI:10.1016/j.jfluchem.2011.02.015

Reference yield:

5-[(tert-Butyldimethylsilyl)oxy]-1,2-dideoxy-3,4-O-(1-methylethylidene)-D-threo-pent-1-yne (319924-30-6) → N-{(2R,3R)-1-[difluoro(phenylseleno)methyl]-2,3-dihydroxypent-4-yn-1-yl}-2-methylpropane-2-sulfinamide (1359718-19-6)

Guidance literature:

Multi-step reaction with 6 steps

1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 20 °C / Inert atmosphere

2: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / ethyl acetate / 7 h / Reflux; Inert atmosphere

3: titanium(IV) tetraethanolate / tetrahydrofuran / 1 h / Inert atmosphere; Reflux

4: tetrabutylammonium triphenyldifluorosilicate / N,N-dimethyl-formamide / 2 h / -60 °C / Molecular sieve; Inert atmosphere

5: trifluoroacetic acid / water / 3 h / 20 °C / Inert atmosphere

6: potassium carbonate / methanol / 1 h / 20 °C / Inert atmosphere

With titanium(IV) tetraethanolate; tetrabutyl ammonium fluoride; potassium carbonate; tetrabutylammonium triphenyldifluorosilicate; trifluoroacetic acid; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In tetrahydrofuran; methanol; water; ethyl acetate; N,N-dimethyl-formamide;

DOI:10.1016/j.jfluchem.2011.02.015

upstream raw materials:

N-{[(4R,5R)-5-ethynyl-2,2-dimethyl-1,3-dioxolan-4-yl]methylene}-2-methylpropane-2-sulfinamide

(SS,2R,3R,4R)-2-tert-butanesulfinamido-3,4-(O-isopropylidene)-6-trimethylsilyl-1,1-difluoro-1-phenylselanyl-hex-5-yne

C₁₉H₂₉F₂NO₃SSeSi

1,2-Dideoxy-3,4-O-(1-methylethylidene)-D-threo-pent-1-ynitol

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 1359718-19-6 N-{(2R,3R)-1-[difluoro(phenylseleno)methyl]-2,3-dihydroxypent-4-yn-1-yl}-2-methylpropane-2-sulfinamide

Send

Send

Metric Ton KG G Pound L ML

Send

Send