N-[(S)-1-{3-[3-(4-Amino-butylamino)-propylamino]-propylcarbamoyl}-2-(4-benzyloxy-phenyl)-ethyl]-butyramide

Base Information

Chemical Name:N-[(S)-1-{3-[3-(4-Amino-butylamino)-propylamino]-propylcarbamoyl}-2-(4-benzyloxy-phenyl)-ethyl]-butyramide
CAS No.:142978-60-7
Molecular Formula:C₃₀H₄₇N₅O₃
Molecular Weight:525.735
Hs Code.:

Synonyms:N-[(S)-1-{3-[3-(4-Amino-butylamino)-propylamino]-propylcarbamoyl}-2-(4-benzyloxy-phenyl)-ethyl]-butyramide

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Chemical Property of N-[(S)-1-{3-[3-(4-Amino-butylamino)-propylamino]-propylcarbamoyl}-2-(4-benzyloxy-phenyl)-ethyl]-butyramide

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Technology Process of N-[(S)-1-{3-[3-(4-Amino-butylamino)-propylamino]-propylcarbamoyl}-2-(4-benzyloxy-phenyl)-ethyl]-butyramide

There total 10 articles about N-[(S)-1-{3-[3-(4-Amino-butylamino)-propylamino]-propylcarbamoyl}-2-(4-benzyloxy-phenyl)-ethyl]-butyramide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 130203-41-7
O-Benzyl-PhTX-di-2',3'-N,N-BOC-334

: 142978-60-7
N-[(S)-1-{3-[3-(4-Amino-butylamino)-propylamino]-propylcarbamoyl}-2-(4-benzyloxy-phenyl)-ethyl]-butyramide

Guidance literature:: With trifluoroacetic acid; In chloroform; for 0.25h; Ambient temperature;
DOI:10.1016/S0040-4020(01)85463-6

Reference yield:

: 68076-41-5
tert-butyl 2-cyanoethyl-{4-[(tert-butoxycarbonyl)amino]butyl}carbamate

: 142978-60-7
N-[(S)-1-{3-[3-(4-Amino-butylamino)-propylamino]-propylcarbamoyl}-2-(4-benzyloxy-phenyl)-ethyl]-butyramide

Guidance literature:: Multi-step reaction with 6 steps

1: 68 percent / LiAlH₄ / diethyl ether / 0.5 h / 0 °C

2: 97 percent / methanol / 12 h / Ambient temperature

3: 98 percent / methanol / 12 h

4: 91 percent / LiAlH₄ / diethyl ether / 0 °C

5: 39 percent / methanol / 0.25 h

6: 67 percent / TFA / CHCl₃ / 0.25 h / Ambient temperature

With lithium aluminium tetrahydride; trifluoroacetic acid; In methanol; diethyl ether; chloroform;
DOI:10.1016/S0040-4020(01)85463-6

Reference yield:

: 68076-39-1
N₁,N₅-di-boc-spermidine

: 142978-60-7
N-[(S)-1-{3-[3-(4-Amino-butylamino)-propylamino]-propylcarbamoyl}-2-(4-benzyloxy-phenyl)-ethyl]-butyramide

Guidance literature:: Multi-step reaction with 5 steps

1: 97 percent / methanol / 12 h / Ambient temperature

2: 98 percent / methanol / 12 h

3: 91 percent / LiAlH₄ / diethyl ether / 0 °C

4: 39 percent / methanol / 0.25 h

5: 67 percent / TFA / CHCl₃ / 0.25 h / Ambient temperature

With lithium aluminium tetrahydride; trifluoroacetic acid; In methanol; diethyl ether; chloroform;
DOI:10.1016/S0040-4020(01)85463-6