ethyl 1-(2-tert-butoxycarbonylaminoethyl)-5-bromo-4-(3-fluorophenyl)-1H-pyrrole-3-carboxylate

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Chemical Name:ethyl 1-(2-tert-butoxycarbonylaminoethyl)-5-bromo-4-(3-fluorophenyl)-1H-pyrrole-3-carboxylate
CAS No.:1352087-59-2
Molecular Formula:C₂₀H₂₄BrFN₂O₄
Molecular Weight:455.324
Hs Code.:

Synonyms:ethyl 1-(2-tert-butoxycarbonylaminoethyl)-5-bromo-4-(3-fluorophenyl)-1H-pyrrole-3-carboxylate

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Chemical Property of ethyl 1-(2-tert-butoxycarbonylaminoethyl)-5-bromo-4-(3-fluorophenyl)-1H-pyrrole-3-carboxylate

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Technology Process of ethyl 1-(2-tert-butoxycarbonylaminoethyl)-5-bromo-4-(3-fluorophenyl)-1H-pyrrole-3-carboxylate

There total 3 articles about ethyl 1-(2-tert-butoxycarbonylaminoethyl)-5-bromo-4-(3-fluorophenyl)-1H-pyrrole-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1352087-58-1
ethyl 5-bromo-4-(3-fluorophenyl)-1H-pyrrole-3-carboxylate

: 39684-80-5
2-(tert-butoxycarbonylamino)ethyl bromide

: 1352087-59-2
ethyl 1-(2-tert-butoxycarbonylaminoethyl)-5-bromo-4-(3-fluorophenyl)-1H-pyrrole-3-carboxylate

Guidance literature:: ethyl 5-bromo-4-(3-fluorophenyl)-1H-pyrrole-3-carboxylate; With sodium hydroxide; tetra(n-butyl)ammonium hydrogensulfate; In acetonitrile;

2-(tert-butoxycarbonylamino)ethyl bromide; In acetonitrile; for 17h; Reflux;

Reference yield:

: 351-46-2
3-(3-Fluorophenyl)acrylic acid ethyl ester

: 1352087-59-2
ethyl 1-(2-tert-butoxycarbonylaminoethyl)-5-bromo-4-(3-fluorophenyl)-1H-pyrrole-3-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium tert-butylate / tetrahydrofuran; mineral oil / 1.5 h / 20 - 25 °C

2.1: N-Bromosuccinimide / tetrahydrofuran / 3 h / Reflux

3.1: sodium hydroxide / tetra(n-butyl)ammonium hydrogensulfate / acetonitrile

3.2: 17 h / Reflux

With N-Bromosuccinimide; potassium tert-butylate; sodium hydroxide; tetra(n-butyl)ammonium hydrogensulfate; In tetrahydrofuran; acetonitrile; mineral oil;

Reference yield:

: 1188162-75-5
ethyl 4-(3-fluorophenyl)-1H-pyrrole-3-carboxylate

: 1352087-59-2
ethyl 1-(2-tert-butoxycarbonylaminoethyl)-5-bromo-4-(3-fluorophenyl)-1H-pyrrole-3-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: N-Bromosuccinimide / tetrahydrofuran / 3 h / Reflux

2.1: sodium hydroxide / tetra(n-butyl)ammonium hydrogensulfate / acetonitrile

2.2: 17 h / Reflux

With N-Bromosuccinimide; sodium hydroxide; tetra(n-butyl)ammonium hydrogensulfate; In tetrahydrofuran; acetonitrile;