N-(3,5-bis(trifluoromethyl)phenyl)-N'-((3R,5S)-5-((tert-butyldiphenylsilyloxy)methyl)pyrrolidin-3-yl)sulfamide

Base Information

Chemical Name:N-(3,5-bis(trifluoromethyl)phenyl)-N'-((3R,5S)-5-((tert-butyldiphenylsilyloxy)methyl)pyrrolidin-3-yl)sulfamide
CAS No.:1372971-97-5
Molecular Formula:C₂₉H₃₃F₆N₃O₃SSi
Molecular Weight:645.741
Hs Code.:

Synonyms:N-(3,5-bis(trifluoromethyl)phenyl)-N'-((3R,5S)-5-((tert-butyldiphenylsilyloxy)methyl)pyrrolidin-3-yl)sulfamide

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Chemical Property of N-(3,5-bis(trifluoromethyl)phenyl)-N'-((3R,5S)-5-((tert-butyldiphenylsilyloxy)methyl)pyrrolidin-3-yl)sulfamide

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Technology Process of N-(3,5-bis(trifluoromethyl)phenyl)-N'-((3R,5S)-5-((tert-butyldiphenylsilyloxy)methyl)pyrrolidin-3-yl)sulfamide

There total 8 articles about N-(3,5-bis(trifluoromethyl)phenyl)-N'-((3R,5S)-5-((tert-butyldiphenylsilyloxy)methyl)pyrrolidin-3-yl)sulfamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 1372972-17-2
C₃₄H₄₁F₆N₃O₅SSi

: 1372971-97-5
N-(3,5-bis(trifluoromethyl)phenyl)-N'-((3R,5S)-5-((tert-butyldiphenylsilyloxy)methyl)pyrrolidin-3-yl)sulfamide

Guidance literature:: C₃₄H₄₁F₆N₃O₅SSi; With trifluoroacetic acid; In dichloromethane; at 0 ℃; for 6h;

With ammonia; In water; pH=8;
DOI:10.1039/c2ob00049k

Reference yield:

: 1159114-52-9
tert-butyl (2S,4R)-4-azido-2-(((tert-butyldiphenylsilyl)oxy)methyl)pyrrolidine-1-carboxylate

: 1372971-97-5
N-(3,5-bis(trifluoromethyl)phenyl)-N'-((3R,5S)-5-((tert-butyldiphenylsilyloxy)methyl)pyrrolidin-3-yl)sulfamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: triphenylphosphine / water

2.1: 1,4-dioxane / 24 h / Reflux

3.1: trifluoroacetic acid / dichloromethane / 6 h / 0 °C

3.2: pH 8

With triphenylphosphine; trifluoroacetic acid; In 1,4-dioxane; dichloromethane; water;
DOI:10.1039/c2ob00049k

Reference yield:

: 74844-91-0,114676-69-6,135042-17-0,227935-38-8,102195-79-9
(2S,4S)-N-tert-butoxycarbonyl-4-hydroxyproline methyl ester

: 1372971-97-5
N-(3,5-bis(trifluoromethyl)phenyl)-N'-((3R,5S)-5-((tert-butyldiphenylsilyloxy)methyl)pyrrolidin-3-yl)sulfamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: triethylamine / dichloromethane

2.1: sodium tetrahydroborate / tetrahydrofuran; methanol

3.1: 1H-imidazole / dichloromethane

4.1: sodium azide / N,N-dimethyl-formamide

5.1: triphenylphosphine / water

6.1: 1,4-dioxane / 24 h / Reflux

7.1: trifluoroacetic acid / dichloromethane / 6 h / 0 °C

7.2: pH 8

With 1H-imidazole; sodium tetrahydroborate; sodium azide; triethylamine; triphenylphosphine; trifluoroacetic acid; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1039/c2ob00049k