N-(2-hydroxyethyl)-N-{(2R)-2-hydroxy-3-[(phenylmethyl)oxy]propyl}-4-methylbenzenesulfonamide

Base Information

Chemical Name:N-(2-hydroxyethyl)-N-{(2R)-2-hydroxy-3-[(phenylmethyl)oxy]propyl}-4-methylbenzenesulfonamide
CAS No.:929278-88-6
Molecular Formula:C₁₉H₂₅NO₅S
Molecular Weight:379.477
Hs Code.:

Synonyms:N-(2-hydroxyethyl)-N-{(2R)-2-hydroxy-3-[(phenylmethyl)oxy]propyl}-4-methylbenzenesulfonamide

Suppliers and Price of N-(2-hydroxyethyl)-N-{(2R)-2-hydroxy-3-[(phenylmethyl)oxy]propyl}-4-methylbenzenesulfonamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-(2-hydroxyethyl)-N-{(2R)-2-hydroxy-3-[(phenylmethyl)oxy]propyl}-4-methylbenzenesulfonamide

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Technology Process of N-(2-hydroxyethyl)-N-{(2R)-2-hydroxy-3-[(phenylmethyl)oxy]propyl}-4-methylbenzenesulfonamide

There total 2 articles about N-(2-hydroxyethyl)-N-{(2R)-2-hydroxy-3-[(phenylmethyl)oxy]propyl}-4-methylbenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 929278-86-4
(2R)-1-[(2-hydroxyethyl)amino]-3-[(phenylmethyl)oxy]-2-propanol

: 98-59-9
p-toluenesulfonyl chloride

: 929278-88-6
N-(2-hydroxyethyl)-N-{(2R)-2-hydroxy-3-[(phenylmethyl)oxy]propyl}-4-methylbenzenesulfonamide

Guidance literature:: With triethylamine; In dichloromethane; at 0 - 20 ℃; for 5h;

Reference yield:

: 14618-80-5
(R)-benzyl glycidol

: 929278-88-6
N-(2-hydroxyethyl)-N-{(2R)-2-hydroxy-3-[(phenylmethyl)oxy]propyl}-4-methylbenzenesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1: propan-1-ol / 16 h / Reflux

2: triethylamine / dichloromethane / 5 h / 0 - 20 °C

With triethylamine; In propan-1-ol; dichloromethane;

Reference yield: 66.0%

: 929278-88-6
N-(2-hydroxyethyl)-N-{(2R)-2-hydroxy-3-[(phenylmethyl)oxy]propyl}-4-methylbenzenesulfonamide

: 929278-90-0
(2R)-4-[(4-methylphenyl)sulfonyl]-2-{[(phenylmethyl)oxy]methyl}-morpholine

Guidance literature:: N-(2-hydroxyethyl)-N-{(2R)-2-hydroxy-3-[(phenylmethyl)oxy]propyl}-4-methylbenzenesulfonamide; With sodium hydride; In tetrahydrofuran; at 0 - 20 ℃; for 1h;

With N-tosylimidazole; In tetrahydrofuran; at 0 - 20 ℃;