(R)-3-Benzylsulfanyl-2-(3-benzylsulfanyl-3-methyl-butyrylamino)-propionic acid

Base Information

• Chemical Name: (R)-3-Benzylsulfanyl-2-(3-benzylsulfanyl-3-methyl-butyrylamino)-propionic acid
• CAS No.: 153893-82-4
• Molecular Formula: C₂₂H₂₇NO₃S₂
• Molecular Weight: 417.593
• Mol file: 153893-82-4.mol

Synonyms:(R)-3-Benzylsulfanyl-2-(3-benzylsulfanyl-3-methyl-butyrylamino)-propionic acid

Chemical Property of (R)-3-Benzylsulfanyl-2-(3-benzylsulfanyl-3-methyl-butyrylamino)-propionic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-3-Benzylsulfanyl-2-(3-benzylsulfanyl-3-methyl-butyrylamino)-propionic acid

There total 4 articles about (R)-3-Benzylsulfanyl-2-(3-benzylsulfanyl-3-methyl-butyrylamino)-propionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

S-benzyl-L-cysteine (3054-01-1,25988-62-9) + 3-Benzylmercapto-3-methyl-butyrylchloride (153893-80-2) → (R)-3-Benzylsulfanyl-2-(3-benzylsulfanyl-3-methyl-butyrylamino)-propionic acid (153893-82-4)

Guidance literature:

With sodium hydroxide; In diethyl ether; for 0.333333h; Ambient temperature;

DOI:10.1248/cpb.41.1066

Reference yield:

3-Methylbutenoic acid (541-47-9) → (R)-3-Benzylsulfanyl-2-(3-benzylsulfanyl-3-methyl-butyrylamino)-propionic acid (153893-82-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 81 percent / piperidine / 22 h / Heating

2: 77.5 percent / thionyl chloride / dimethylformamide / 2 h / Ambient temperature

3: 96 percent / 2 N aq. NaOH / diethyl ether / 0.33 h / Ambient temperature

With piperidine; sodium hydroxide; thionyl chloride; In diethyl ether; N,N-dimethyl-formamide;

DOI:10.1248/cpb.41.1066

Reference yield:

3-methyl-3-(phenylmethylthio)butanoic acid (7536-39-2) → (R)-3-Benzylsulfanyl-2-(3-benzylsulfanyl-3-methyl-butyrylamino)-propionic acid (153893-82-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 77.5 percent / thionyl chloride / dimethylformamide / 2 h / Ambient temperature

2: 96 percent / 2 N aq. NaOH / diethyl ether / 0.33 h / Ambient temperature

With sodium hydroxide; thionyl chloride; In diethyl ether; N,N-dimethyl-formamide;

DOI:10.1248/cpb.41.1066

upstream raw materials:

S-benzyl-L-cysteine

3-Benzylmercapto-3-methyl-butyrylchloride

3-Methylbutenoic acid

3-methyl-3-(phenylmethylthio)butanoic acid