ethyl (R)-2,2-dimethyl-4-(4-(3-(2-methylpyrrolidin-1-yl)propoxy)-phenyl)-4-oxobutanoate

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Chemical Name:ethyl (R)-2,2-dimethyl-4-(4-(3-(2-methylpyrrolidin-1-yl)propoxy)-phenyl)-4-oxobutanoate
CAS No.:1357019-40-9
Molecular Formula:C₂₂H₃₃NO₄
Molecular Weight:375.508
Hs Code.:

Synonyms:ethyl (R)-2,2-dimethyl-4-(4-(3-(2-methylpyrrolidin-1-yl)propoxy)-phenyl)-4-oxobutanoate

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Chemical Property of ethyl (R)-2,2-dimethyl-4-(4-(3-(2-methylpyrrolidin-1-yl)propoxy)-phenyl)-4-oxobutanoate

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Technology Process of ethyl (R)-2,2-dimethyl-4-(4-(3-(2-methylpyrrolidin-1-yl)propoxy)-phenyl)-4-oxobutanoate

There total 8 articles about ethyl (R)-2,2-dimethyl-4-(4-(3-(2-methylpyrrolidin-1-yl)propoxy)-phenyl)-4-oxobutanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 1367309-22-5
C₁₇H₂₃ClO₄

: 765-38-8,41720-98-3,59335-84-1,79171-53-2
(R)-(-)-2-methylpyrrolidine

: 1357019-40-9
ethyl (R)-2,2-dimethyl-4-(4-(3-(2-methylpyrrolidin-1-yl)propoxy)-phenyl)-4-oxobutanoate

Guidance literature:: With potassium carbonate; potassium iodide; In acetonitrile; at 80 ℃;
DOI:10.1016/j.bmcl.2011.11.037

Reference yield:

: 1224582-91-5
ethyl 4-(4-hydroxyphenyl)-2,2-dimethyl-4-oxobutanoate

: 1357019-40-9
ethyl (R)-2,2-dimethyl-4-(4-(3-(2-methylpyrrolidin-1-yl)propoxy)-phenyl)-4-oxobutanoate

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / acetonitrile / 65 °C

2: potassium carbonate; potassium iodide / acetonitrile / 80 °C

With potassium carbonate; potassium iodide; In acetonitrile;
DOI:10.1016/j.bmcl.2011.11.037

Reference yield:

: 17347-61-4
2,2-dimethylsuccinic anhydride

: 1357019-40-9
ethyl (R)-2,2-dimethyl-4-(4-(3-(2-methylpyrrolidin-1-yl)propoxy)-phenyl)-4-oxobutanoate

Guidance literature:: Multi-step reaction with 5 steps

1: tetrahydrofuran / 0 - 20 °C

2: hydrogen bromide / Reflux

3: sulfuric acid

4: potassium carbonate / acetonitrile / 65 °C

5: potassium carbonate; potassium iodide / acetonitrile / 80 °C

With sulfuric acid; hydrogen bromide; potassium carbonate; potassium iodide; In tetrahydrofuran; acetonitrile;
DOI:10.1016/j.bmcl.2011.11.037