(2RS,5RS,9SR,10RS)-9-tert-butyldiphenylsilyloxy-6,10-dimethyl-2-pivaloyloxyspiro<4.5>dec-6-en-8-one ethylene dithioacetal

Base Information

Chemical Name:(2RS,5RS,9SR,10RS)-9-tert-butyldiphenylsilyloxy-6,10-dimethyl-2-pivaloyloxyspiro<4.5>dec-6-en-8-one ethylene dithioacetal
CAS No.:111675-29-7
Molecular Formula:C₃₅H₄₈O₃S₂Si
Molecular Weight:608.982
Hs Code.:

Synonyms:(2RS,5RS,9SR,10RS)-9-tert-butyldiphenylsilyloxy-6,10-dimethyl-2-pivaloyloxyspiro<4.5>dec-6-en-8-one ethylene dithioacetal

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Chemical Property of (2RS,5RS,9SR,10RS)-9-tert-butyldiphenylsilyloxy-6,10-dimethyl-2-pivaloyloxyspiro<4.5>dec-6-en-8-one ethylene dithioacetal

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Technology Process of (2RS,5RS,9SR,10RS)-9-tert-butyldiphenylsilyloxy-6,10-dimethyl-2-pivaloyloxyspiro<4.5>dec-6-en-8-one ethylene dithioacetal

There total 6 articles about (2RS,5RS,9SR,10RS)-9-tert-butyldiphenylsilyloxy-6,10-dimethyl-2-pivaloyloxyspiro<4.5>dec-6-en-8-one ethylene dithioacetal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 540-63-6
ethane-1,2-dithiol

: 127650-68-4
(2RS,5RS,9SR,10RS)-9-tert-butyldiphenylsilyloxy-6,10-dimethyl-2-pivaloyloxyspiro<4.5>dec-6-en-8-one

: 111675-29-7
(2RS,5RS,9SR,10RS)-9-tert-butyldiphenylsilyloxy-6,10-dimethyl-2-pivaloyloxyspiro<4.5>dec-6-en-8-one ethylene dithioacetal

Guidance literature:: With boron trifluoride diethyl etherate; In dichloromethane; for 1.5h; Ambient temperature;

Reference yield:

: 101415-95-6
2,2-Dimethyl-propionic acid (2S,5S,10R)-6,10-dimethyl-8-trimethylsilanyloxy-spiro[4.5]deca-6,8-dien-2-yl ester

: 111675-29-7
(2RS,5RS,9SR,10RS)-9-tert-butyldiphenylsilyloxy-6,10-dimethyl-2-pivaloyloxyspiro<4.5>dec-6-en-8-one ethylene dithioacetal

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) triphenyl phosphite ozonide, 2.) Et₃N, triphenylphosphine / 1.) CH₂Cl₂, -50 deg C, 8 h, 2.) CH₂Cl₂, ether, r.t., 5 h

2: 98 percent / imidazole / dimethylformamide / 12 h / 50 °C

3: 66 percent / BF₃*Et₂O / CH₂Cl₂ / 1.5 h / Ambient temperature

With 1H-imidazole; triphenyl phosphite ozonide; boron trifluoride diethyl etherate; triethylamine; triphenylphosphine; In dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 92463-07-5
(2RS,5RS,10SR)-6,10-dimethyl-2-pivaloyloxyspiro<4.5>dec-6-en-8-one

: 111675-29-7
(2RS,5RS,9SR,10RS)-9-tert-butyldiphenylsilyloxy-6,10-dimethyl-2-pivaloyloxyspiro<4.5>dec-6-en-8-one ethylene dithioacetal

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) LDA / 1.) DME, -18 deg C, 1 h, 2.) DME, r.t., 2 h

2: 1.) triphenyl phosphite ozonide, 2.) Et₃N, triphenylphosphine / 1.) CH₂Cl₂, -50 deg C, 8 h, 2.) CH₂Cl₂, ether, r.t., 5 h

3: 98 percent / imidazole / dimethylformamide / 12 h / 50 °C

4: 66 percent / BF₃*Et₂O / CH₂Cl₂ / 1.5 h / Ambient temperature

With 1H-imidazole; triphenyl phosphite ozonide; boron trifluoride diethyl etherate; triethylamine; triphenylphosphine; lithium diisopropyl amide; In dichloromethane; N,N-dimethyl-formamide;