7-methyl-2-(4-(trifluoromethyl)phenyl)imidazo[1,2-a]pyridine

Base Information

• Chemical Name: 7-methyl-2-(4-(trifluoromethyl)phenyl)imidazo[1,2-a]pyridine
• CAS No.: 1429518-13-7
• Molecular Formula: C₁₅H₁₁F₃N₂
• Molecular Weight: 276.261
• Mol file: 1429518-13-7.mol

Synonyms:7-methyl-2-(4-(trifluoromethyl)phenyl)imidazo[1,2-a]pyridine

Chemical Property of 7-methyl-2-(4-(trifluoromethyl)phenyl)imidazo[1,2-a]pyridine

Chemical Property:

Purity/Quality:

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Technology Process of 7-methyl-2-(4-(trifluoromethyl)phenyl)imidazo[1,2-a]pyridine

There total 1 articles about 7-methyl-2-(4-(trifluoromethyl)phenyl)imidazo[1,2-a]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

2-Amino-4-methylpyridine (695-34-1) + 1-(4-trifluoromethylphenyl)ethanone (709-63-7) → 7-methyl-2-(4-(trifluoromethyl)phenyl)imidazo[1,2-a]pyridine (1429518-13-7)

Guidance literature:

With 1,10-Phenanthroline; copper(II) acetate monohydrate; zinc(II) iodide; In 1,2-dichloro-benzene; at 120 ℃; for 24h;

DOI:10.1002/adsc.201300298

Reference yield: 77.0%

7-methyl-2-(4-(trifluoromethyl)phenyl)imidazo[1,2-a]pyridine (1429518-13-7) → 3-bromo-7-methyl-2-(4-(trifluoromethyl)phenyl)imidazo[1,2-a]pyridine

Guidance literature:

With tetrabutylammomium bromide; In N,N-dimethyl-formamide; acetonitrile; at 20 ℃; regioselective reaction; Electrochemical reaction; Electrolysis; Green chemistry;

DOI:10.1039/d1gc01069g

Reference yield: 74.0%

7-methyl-2-(4-(trifluoromethyl)phenyl)imidazo[1,2-a]pyridine (1429518-13-7) → 3-chloro-7-methyl-2-(4-(trifluoromethyl)phenyl)imidazo[1,2-a]pyridine

Guidance literature:

With tetraethylammonium chloride; In N,N-dimethyl-formamide; acetonitrile; at 20 ℃; regioselective reaction; Electrochemical reaction; Electrolysis; Green chemistry;

DOI:10.1039/d1gc01069g

upstream raw materials:

2-Amino-4-methylpyridine

1-(4-trifluoromethylphenyl)ethanone