[2-(tert-butyl-dimethyl-silanyloxy)-2-(3-chloro-phenyl)-ethyl]-(1-methyl-2-{4-[2-oxo-2-(toluene-4-sulfonylamino)-ethyl]-phenylamino}-ethyl)-carbamic acid tert-butyl ester

Base Information

Chemical Name:[2-(tert-butyl-dimethyl-silanyloxy)-2-(3-chloro-phenyl)-ethyl]-(1-methyl-2-{4-[2-oxo-2-(toluene-4-sulfonylamino)-ethyl]-phenylamino}-ethyl)-carbamic acid tert-butyl ester
CAS No.:1026596-90-6
Molecular Formula:C₃₇H₅₂ClN₃O₆SSi
Molecular Weight:730.441
Hs Code.:

[2-(<i>tert</i>-butyl-dimethyl-silanyloxy)-2-(3-chloro-phenyl)-ethyl]-(1-methyl-2-{4-[2-oxo-2-(toluene-4-sulfonylamino)-ethyl]-phenylamino}-ethyl)-carbamic acid <i>tert</i>-butyl ester

Synonyms:[2-(tert-butyl-dimethyl-silanyloxy)-2-(3-chloro-phenyl)-ethyl]-(1-methyl-2-{4-[2-oxo-2-(toluene-4-sulfonylamino)-ethyl]-phenylamino}-ethyl)-carbamic acid tert-butyl ester

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Chemical Property of [2-(tert-butyl-dimethyl-silanyloxy)-2-(3-chloro-phenyl)-ethyl]-(1-methyl-2-{4-[2-oxo-2-(toluene-4-sulfonylamino)-ethyl]-phenylamino}-ethyl)-carbamic acid tert-butyl ester

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Technology Process of [2-(tert-butyl-dimethyl-silanyloxy)-2-(3-chloro-phenyl)-ethyl]-(1-methyl-2-{4-[2-oxo-2-(toluene-4-sulfonylamino)-ethyl]-phenylamino}-ethyl)-carbamic acid tert-butyl ester

There total 4 articles about [2-(tert-butyl-dimethyl-silanyloxy)-2-(3-chloro-phenyl)-ethyl]-(1-methyl-2-{4-[2-oxo-2-(toluene-4-sulfonylamino)-ethyl]-phenylamino}-ethyl)-carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 402513-98-8
N-[2-(4-aminophenyl)acetyl]-4-methylbenzenesulfonamide

: 174891-03-3
1,1-dimethylethyl ((2R)-2-(3-chlorophenyl)-2-{[(1,1-dimethylethyl)(dimethyl)silyl]oxy}ethyl)[(1R)-1-methyl-2-oxoethyl]carbamate

: 1026596-90-6
[2-(tert-butyl-dimethyl-silanyloxy)-2-(3-chloro-phenyl)-ethyl]-(1-methyl-2-{4-[2-oxo-2-(toluene-4-sulfonylamino)-ethyl]-phenylamino}-ethyl)-carbamic acid tert-butyl ester

Guidance literature:: With sodium tris(acetoxy)borohydride; acetic acid; In dichloromethane; at 20 ℃;
DOI:10.1021/jm0101500

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 1026596-90-6
[2-(tert-butyl-dimethyl-silanyloxy)-2-(3-chloro-phenyl)-ethyl]-(1-methyl-2-{4-[2-oxo-2-(toluene-4-sulfonylamino)-ethyl]-phenylamino}-ethyl)-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 96 percent / 0.25 h / 90 - 95 °C

2: 96 percent / DIBAL / toluene / 1 h / -78 °C

3: 152 mg / NaBH(OAc)3; AcOH / CH₂Cl₂ / 20 °C

With sodium tris(acetoxy)borohydride; diisobutylaluminium hydride; acetic acid; In dichloromethane; toluene;
DOI:10.1021/jm0101500

Reference yield:

: 16273-37-3,32222-43-8,52950-16-0,61008-98-8
(R)-3-chloromandelic acid

: 1026596-90-6
[2-(tert-butyl-dimethyl-silanyloxy)-2-(3-chloro-phenyl)-ethyl]-(1-methyl-2-{4-[2-oxo-2-(toluene-4-sulfonylamino)-ethyl]-phenylamino}-ethyl)-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: 56.59 g / H₂SO₄ / methanol / 4 h / Heating

2.1: 97 percent / imidazole / dimethylformamide / 7 h

3.1: DIBAL / diethyl ether; toluene / 1.5 h / -78 °C

3.2: 95 percent / 4 A molecular sieves; NaBH(OAc)3 / CH₂Cl₂; acetic acid / 2 h

4.1: 96 percent / 0.25 h / 90 - 95 °C

5.1: 96 percent / DIBAL / toluene / 1 h / -78 °C

6.1: 152 mg / NaBH(OAc)3; AcOH / CH₂Cl₂ / 20 °C

With 1H-imidazole; sulfuric acid; sodium tris(acetoxy)borohydride; diisobutylaluminium hydride; acetic acid; In methanol; diethyl ether; dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm0101500