N-(4'-cyanophenyl)-5-(4''-formyl-2'',6''-dimethylphenoxy)-4-aminosulfonyl-2-nitroaniline

Base Information

• Chemical Name: N-(4'-cyanophenyl)-5-(4''-formyl-2'',6''-dimethylphenoxy)-4-aminosulfonyl-2-nitroaniline
• CAS No.: 1393736-01-0
• Molecular Formula: C₂₂H₁₈N₄O₆S
• Molecular Weight: 466.474

Synonyms:N-(4'-cyanophenyl)-5-(4''-formyl-2'',6''-dimethylphenoxy)-4-aminosulfonyl-2-nitroaniline

Chemical Property of N-(4'-cyanophenyl)-5-(4''-formyl-2'',6''-dimethylphenoxy)-4-aminosulfonyl-2-nitroaniline

Chemical Property:

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Technology Process of N-(4'-cyanophenyl)-5-(4''-formyl-2'',6''-dimethylphenoxy)-4-aminosulfonyl-2-nitroaniline

There total 3 articles about N-(4'-cyanophenyl)-5-(4''-formyl-2'',6''-dimethylphenoxy)-4-aminosulfonyl-2-nitroaniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

4-hydroxy-3,5-dimethylbenzaldehyde (2233-18-3) + 2-amino-4-chloro-N2-(4'-cyanophenyl)-5-aminosulfonyl-nitrobenzene (1393735-99-3) → N-(4'-cyanophenyl)-5-(4''-formyl-2'',6''-dimethylphenoxy)-4-aminosulfonyl-2-nitroaniline (1393736-01-0)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 130 ℃; for 5h;

DOI:10.1021/jm3007678

Reference yield:

2,4-dichloronitrobenzene (611-06-3) → N-(4'-cyanophenyl)-5-(4''-formyl-2'',6''-dimethylphenoxy)-4-aminosulfonyl-2-nitroaniline (1393736-01-0)

Guidance literature:

Multi-step reaction with 4 steps

1: chlorosulfonic acid / 0 - 140 °C

2: ammonium hydroxide / tetrahydrofuran / 0 °C

3: potassium tert-butylate / N,N-dimethyl-formamide / 0 - 20 °C

4: potassium carbonate / N,N-dimethyl-formamide / 5 h / 130 °C

With chlorosulfonic acid; ammonium hydroxide; potassium tert-butylate; potassium carbonate; In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.1021/jm3007678

Reference yield:

→ N-(4'-cyanophenyl)-5-(4''-formyl-2'',6''-dimethylphenoxy)-4-aminosulfonyl-2-nitroaniline (1393736-01-0)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 190 ℃; for 0.25h; Microwave irradiation;

upstream raw materials:

4-hydroxy-3,5-dimethylbenzaldehyde

2-amino-4-chloro-N₂-(4'-cyanophenyl)-5-aminosulfonyl-nitrobenzene

2,4-dichloronitrobenzene

Downstream raw materials:

C₂₄H₂₁N₅O₃S

5-(4''-cyanoethyl-2'',6''-dimethylphenoxy)-N₁-(4'-cyanophenyl)-4-aminosulfonyl-1,2-phenylenediamine

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