1-(4-Fluorophenyl)-3-[1-[2-(2-imidazolidinon-1-yl)ethyl]-4-piperidinyl]-N-methyl-1H-indole-5-carboxamide

Base Information

Chemical Name:1-(4-Fluorophenyl)-3-[1-[2-(2-imidazolidinon-1-yl)ethyl]-4-piperidinyl]-N-methyl-1H-indole-5-carboxamide
CAS No.:330944-21-3
Molecular Formula:C₂₆H₃₀FN₅O₂
Molecular Weight:463.555
Hs Code.:

Synonyms:1-(4-Fluorophenyl)-3-[1-[2-(2-imidazolidinon-1-yl)ethyl]-4-piperidinyl]-N-methyl-1H-indole-5-carboxamide

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Chemical Property of 1-(4-Fluorophenyl)-3-[1-[2-(2-imidazolidinon-1-yl)ethyl]-4-piperidinyl]-N-methyl-1H-indole-5-carboxamide

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Technology Process of 1-(4-Fluorophenyl)-3-[1-[2-(2-imidazolidinon-1-yl)ethyl]-4-piperidinyl]-N-methyl-1H-indole-5-carboxamide

There total 6 articles about 1-(4-Fluorophenyl)-3-[1-[2-(2-imidazolidinon-1-yl)ethyl]-4-piperidinyl]-N-methyl-1H-indole-5-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

: 2387-20-4
1-(2-chloroethyl)imidazolidin-2-one

: 330944-17-7
1-(4-fluorophenyl)-N-methyl-3-(piperidin-4-yl)-1H-indole-5-carboxamide

: 330944-21-3
1-(4-Fluorophenyl)-3-[1-[2-(2-imidazolidinon-1-yl)ethyl]-4-piperidinyl]-N-methyl-1H-indole-5-carboxamide

Guidance literature:: With potassium carbonate; potassium iodide; In various solvent(s); for 8h; Heating;
DOI:10.1016/S0968-0896(02)00459-5

Reference yield:

: 41979-39-9
4-piperidone hydrochloride

: 330944-21-3
1-(4-Fluorophenyl)-3-[1-[2-(2-imidazolidinon-1-yl)ethyl]-4-piperidinyl]-N-methyl-1H-indole-5-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: 100 percent / TFA / acetic acid / 1.5 h / Heating

2: 58 percent / H₂ / PtO₂ / acetic acid; trifluoroacetic acid / 5 h / 20 °C / 2206.52 Torr

3: 59 percent / K₂CO₃; KI / various solvent(s) / 8 h / Heating

With hydrogen; potassium carbonate; trifluoroacetic acid; potassium iodide; platinum(IV) oxide; In acetic acid; trifluoroacetic acid;
DOI:10.1016/S0968-0896(02)00459-5

Reference yield:

: 138900-18-2
1-(4-fluorophenyl)-5-cyano-1H-indole

: 330944-21-3
1-(4-Fluorophenyl)-3-[1-[2-(2-imidazolidinon-1-yl)ethyl]-4-piperidinyl]-N-methyl-1H-indole-5-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: 96 percent / KOH; H₂O / ethanol / 24 h / Heating

2.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 0.83 h / 20 °C

2.2: 73 percent / tetrahydrofuran / 1.08 h / 0 - 20 °C

3.1: 100 percent / TFA / acetic acid / 1.5 h / Heating

4.1: 58 percent / H₂ / PtO₂ / acetic acid; trifluoroacetic acid / 5 h / 20 °C / 2206.52 Torr

5.1: 59 percent / K₂CO₃; KI / various solvent(s) / 8 h / Heating

With potassium hydroxide; water; hydrogen; potassium carbonate; 1,1'-carbonyldiimidazole; trifluoroacetic acid; potassium iodide; platinum(IV) oxide; In tetrahydrofuran; ethanol; acetic acid; trifluoroacetic acid;
DOI:10.1016/S0968-0896(02)00459-5