1-[(5Z)-5-({1-[2,4-bis(trifluoromethyl)benzyl]piperidin-4-yl}methylidene)-2-oxo-2,5-dihydro-1,3-thiazol-4-yl]-N,N-dimethyl-L-prolinamide

Base Information

Chemical Name:1-[(5Z)-5-({1-[2,4-bis(trifluoromethyl)benzyl]piperidin-4-yl}methylidene)-2-oxo-2,5-dihydro-1,3-thiazol-4-yl]-N,N-dimethyl-L-prolinamide
CAS No.:1422128-63-9
Molecular Formula:C₂₅H₂₈F₆N₄O₂S
Molecular Weight:562.579
Hs Code.:

Synonyms:1-[(5Z)-5-({1-[2,4-bis(trifluoromethyl)benzyl]piperidin-4-yl}methylidene)-2-oxo-2,5-dihydro-1,3-thiazol-4-yl]-N,N-dimethyl-L-prolinamide

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Chemical Property of 1-[(5Z)-5-({1-[2,4-bis(trifluoromethyl)benzyl]piperidin-4-yl}methylidene)-2-oxo-2,5-dihydro-1,3-thiazol-4-yl]-N,N-dimethyl-L-prolinamide

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Technology Process of 1-[(5Z)-5-({1-[2,4-bis(trifluoromethyl)benzyl]piperidin-4-yl}methylidene)-2-oxo-2,5-dihydro-1,3-thiazol-4-yl]-N,N-dimethyl-L-prolinamide

There total 6 articles about 1-[(5Z)-5-({1-[2,4-bis(trifluoromethyl)benzyl]piperidin-4-yl}methylidene)-2-oxo-2,5-dihydro-1,3-thiazol-4-yl]-N,N-dimethyl-L-prolinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1422129-02-9
1-[2,4-bis(trifluoromethyl)benzyl]piperidine-4-carbaldehyde

: 1422130-04-8
N,N-dimethyl-1-(2-oxo-2,5-dihydro-1,3-thiazol-4-yl)-L-prolinamide

: 1422128-63-9
1-[(5Z)-5-({1-[2,4-bis(trifluoromethyl)benzyl]piperidin-4-yl}methylidene)-2-oxo-2,5-dihydro-1,3-thiazol-4-yl]-N,N-dimethyl-L-prolinamide

Guidance literature:: With piperdinium acetate; In isopropyl alcohol; at 60 ℃;

Reference yield:

: 140690-56-8
2,4-bis(trifluoromethyl)benzyl bromide

: 1422128-63-9
1-[(5Z)-5-({1-[2,4-bis(trifluoromethyl)benzyl]piperidin-4-yl}methylidene)-2-oxo-2,5-dihydro-1,3-thiazol-4-yl]-N,N-dimethyl-L-prolinamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium carbonate / ethanol; N,N-dimethyl-formamide / 2 h / 20 °C

1.2: 1 h / 20 °C

2.1: piperdinium acetate / isopropyl alcohol / 60 °C

With piperdinium acetate; potassium carbonate; In ethanol; N,N-dimethyl-formamide; isopropyl alcohol;

Reference yield:

: 6457-49-4
4-piperidinemethanol

: 1422128-63-9
1-[(5Z)-5-({1-[2,4-bis(trifluoromethyl)benzyl]piperidin-4-yl}methylidene)-2-oxo-2,5-dihydro-1,3-thiazol-4-yl]-N,N-dimethyl-L-prolinamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium carbonate / ethanol; N,N-dimethyl-formamide / 2 h / 20 °C

1.2: 1 h / 20 °C

2.1: piperdinium acetate / isopropyl alcohol / 60 °C

With piperdinium acetate; potassium carbonate; In ethanol; N,N-dimethyl-formamide; isopropyl alcohol;