rac-6-<3-(4-acetyl-3-hydroxy-2-propylphenoxy)propoxy>-3,4-dihydro-2,5,7,8-tetramethyl-2H-1-benzopyran-2-carboxylic acid methyl ester

Base Information

Chemical Name:rac-6-<3-(4-acetyl-3-hydroxy-2-propylphenoxy)propoxy>-3,4-dihydro-2,5,7,8-tetramethyl-2H-1-benzopyran-2-carboxylic acid methyl ester
CAS No.:96566-99-3
Molecular Formula:C₂₉H₃₈O₇
Molecular Weight:498.617
Hs Code.:

Synonyms:rac-6-<3-(4-acetyl-3-hydroxy-2-propylphenoxy)propoxy>-3,4-dihydro-2,5,7,8-tetramethyl-2H-1-benzopyran-2-carboxylic acid methyl ester

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Chemical Property of rac-6-<3-(4-acetyl-3-hydroxy-2-propylphenoxy)propoxy>-3,4-dihydro-2,5,7,8-tetramethyl-2H-1-benzopyran-2-carboxylic acid methyl ester

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Technology Process of rac-6-<3-(4-acetyl-3-hydroxy-2-propylphenoxy)propoxy>-3,4-dihydro-2,5,7,8-tetramethyl-2H-1-benzopyran-2-carboxylic acid methyl ester

There total 5 articles about rac-6-<3-(4-acetyl-3-hydroxy-2-propylphenoxy)propoxy>-3,4-dihydro-2,5,7,8-tetramethyl-2H-1-benzopyran-2-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 86646-83-5
methyl 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylate

: 96566-99-3
rac-6-<3-(4-acetyl-3-hydroxy-2-propylphenoxy)propoxy>-3,4-dihydro-2,5,7,8-tetramethyl-2H-1-benzopyran-2-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) NaH / 1.) DMF, room temperature, 45 min, 2.) room temperature, 90 h

2: 1.) borane-dimethyl sulfide, 2.) 3 N NaOH, 30percent H₂O₂ / 1.) THF, 0-5 deg C, 1.5 h, 2.) H₂O, 5-10 deg C, 1 h

3: 0.461 g / Et₃N / CH₂Cl₂ / 0.75 h / Ambient temperature

4: NaI / acetone / 43.5 h / Ambient temperature

5: 1.) K₂CO₃ / 1.) DMF, room temperature, 1 h, 2.) DMF, a) room temperature, 30 min, b) 60 deg C, 31 h

With sodium hydroxide; dimethylsulfide borane complex; dihydrogen peroxide; sodium hydride; potassium carbonate; triethylamine; sodium iodide; In dichloromethane; acetone;
DOI:10.1021/jm00128a028

Reference yield:

: 96566-95-9
rac-3,4-dihydro-2,5,7,8-tetramethyl-6-(2-propenyloxy)-2H-1-benzopyran-2-carboxylic acid methyl ester

: 96566-99-3
rac-6-<3-(4-acetyl-3-hydroxy-2-propylphenoxy)propoxy>-3,4-dihydro-2,5,7,8-tetramethyl-2H-1-benzopyran-2-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) borane-dimethyl sulfide, 2.) 3 N NaOH, 30percent H₂O₂ / 1.) THF, 0-5 deg C, 1.5 h, 2.) H₂O, 5-10 deg C, 1 h

2: 0.461 g / Et₃N / CH₂Cl₂ / 0.75 h / Ambient temperature

3: NaI / acetone / 43.5 h / Ambient temperature

4: 1.) K₂CO₃ / 1.) DMF, room temperature, 1 h, 2.) DMF, a) room temperature, 30 min, b) 60 deg C, 31 h

With sodium hydroxide; dimethylsulfide borane complex; dihydrogen peroxide; potassium carbonate; triethylamine; sodium iodide; In dichloromethane; acetone;
DOI:10.1021/jm00128a028

Reference yield:

: 96566-96-0
rac-3,4-dihydro-2,5,7,8-tetramethyl-6-(3-hydroxypropoxy)-2H-1-benzopyran-2-carboxylic acid methyl ester

: 96566-99-3
rac-6-<3-(4-acetyl-3-hydroxy-2-propylphenoxy)propoxy>-3,4-dihydro-2,5,7,8-tetramethyl-2H-1-benzopyran-2-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 0.461 g / Et₃N / CH₂Cl₂ / 0.75 h / Ambient temperature

2: NaI / acetone / 43.5 h / Ambient temperature

3: 1.) K₂CO₃ / 1.) DMF, room temperature, 1 h, 2.) DMF, a) room temperature, 30 min, b) 60 deg C, 31 h

With potassium carbonate; triethylamine; sodium iodide; In dichloromethane; acetone;
DOI:10.1021/jm00128a028