5-Deoxy-D-ribose

Base Information

• Chemical Name: 5-Deoxy-D-ribose
• CAS No.: 13039-75-3
• Molecular Formula: C5H10O4
• Molecular Weight: 134.132
• Hs Code.: 2912491000
• Mol file: 13039-75-3.mol

Synonyms:Ribose,5-deoxy-, D- (5CI);

Chemical Property of 5-Deoxy-D-ribose

Chemical Property:

• Refractive Index: 1.497
• Boiling Point: 294.5 °C at 760 mmHg
• PKA: 12.63±0.20(Predicted)
• Flash Point: 146.1 °C
• PSA: 69.92000
• Density: 1.314 g/cm³
• LogP: -1.55470
• Storage Temp.: 2-8°C
• Solubility.: Methanol (Sparingly), Water (Sparingly)

Purity/Quality:

99% ^*data from raw suppliers

5-Deoxy-D-ribose ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-37/39

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 5-Deoxy-D-ribose is used in the process for preparing Capecitabine and β-trialkyl carbonate nucleosides. Used in the process for preparing Capecitabine and β-trialkyl carbonate nucleosides.

Technology Process of 5-Deoxy-D-ribose

There total 12 articles about 5-Deoxy-D-ribose which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

methyl 5-deoxy-2,3-O-isopropylidene-β-D-ribofuranoside (23202-81-5) → 5′-deoxyribose (13039-75-3)

Guidance literature:

With sulfuric acid; In water; for 3h; Heating;

DOI:10.1016/0008-6215(87)80180-5

Reference yield:

5'-deoxyadenosine (4754-39-6) → 5′-deoxyribose (13039-75-3)

Guidance literature:

With 5′-methylthioadenosinenucleosidase; water; at 25 ℃; Kinetics; Enzymatic reaction;

DOI:10.1021/acschembio.6b00144

Reference yield:

→ DL-5-deoxy-arabinose (5531-24-8,13039-56-0,13039-75-3,13039-77-5,13039-78-6,16777-96-1,18555-65-2,49694-62-4,67968-47-2,87900-75-2,90865-54-6)

Guidance literature:

upstream raw materials:

O²,O³-diacetyl-5-deoxy-D-ribose

methyl 5-deoxy-2,3-O-isopropylidene-β-D-ribofuranoside

methyl 2,3-di-O-benzyl-5-deoxy-β-d-ribofuranoside

((3aR,4R,6R,6aR)-6-methoxy-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methanol

Downstream raw materials:

1,2,3-tri-O-acetyl-5-deoxy-β-D-ribofuranose

(3S,4R,5R,6R)-1,3,4,5,6-pentahydroxyheptan-2-one

D-erythro-5-deoxy-[2]pentosulose-bis-(4-bromo-phenylhydrazone)

Refernces

• 1、 Namanja-Magliano, Hilda A.,Stratton, Christopher F.,Schramm, Vern L.. "Transition State Structure and Inhibition of Rv0091, a 5′-Deoxyadenosine/5′-methylthioadenosine Nucleosidase from Mycobacterium tuberculosis". . p. 1669 - 1676. Retrieved 2016.
• 2、 -. "5'-Deoxy-5-fluorouridine". . . Retrieved 2008/06/13.