dimethyl 4-(methylenetriphenylphosphoniumchloride)pyridine-2,6-dicarboxylate

Base Information

• Chemical Name: dimethyl 4-(methylenetriphenylphosphoniumchloride)pyridine-2,6-dicarboxylate
• CAS No.: 1072925-95-1
• Molecular Formula: C₂₈H₂₅NO₄P*Cl
• Molecular Weight: 505.938
• Mol file: 1072925-95-1.mol

Synonyms:dimethyl 4-(methylenetriphenylphosphoniumchloride)pyridine-2,6-dicarboxylate

Chemical Property of dimethyl 4-(methylenetriphenylphosphoniumchloride)pyridine-2,6-dicarboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of dimethyl 4-(methylenetriphenylphosphoniumchloride)pyridine-2,6-dicarboxylate

There total 2 articles about dimethyl 4-(methylenetriphenylphosphoniumchloride)pyridine-2,6-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.4%

dimethyl-4-(chloromethyl)pyridine-2,6-dimethcarboxylate (1072925-93-9) + triphenylphosphine (603-35-0) → dimethyl 4-(methylenetriphenylphosphoniumchloride)pyridine-2,6-dicarboxylate (1072925-95-1)

Guidance literature:

In N,N-dimethyl-formamide; for 5h; Reflux;

DOI:10.1016/j.saa.2007.12.006

Reference yield:

dimethyl 4-(hydroxylmethyl)pyridine-2,6-dicarboxylate (852936-60-8) → dimethyl 4-(methylenetriphenylphosphoniumchloride)pyridine-2,6-dicarboxylate (1072925-95-1)

Guidance literature:

Multi-step reaction with 2 steps

1: thionyl chloride / chloroform / -5 °C / Inert atmosphere

2: N,N-dimethyl-formamide; benzene / 6 h / Reflux

With thionyl chloride; In chloroform; N,N-dimethyl-formamide; benzene;

DOI:10.1080/00397911.2010.518275

Reference yield: 78.3%

dimethyl 4-(methylenetriphenylphosphoniumchloride)pyridine-2,6-dicarboxylate (1072925-95-1) + p-xylenebis(triphenylphosphonium) dibromide (40817-03-6) → dimethyl 4-(4-(2-(2,6-bis(methoxycarbonyl)pyridine-4-yl)vinyl)styryl)pyridine-2,6-dicarboxylate (1357500-95-8)

Guidance literature:

With sodium methylate; In methanol; at -20 - 20 ℃; Inert atmosphere;

DOI:10.1016/j.saa.2007.12.006

upstream raw materials:

dimethyl-4-(chloromethyl)pyridine-2,6-dimethcarboxylate

triphenylphosphine

dimethyl 4-(hydroxylmethyl)pyridine-2,6-dicarboxylate

Downstream raw materials:

dimethyl 4-(4-(2-(2,6-bis(methoxycarbonyl)pyridine-4-yl)vinyl)styryl)pyridine-2,6-dicarboxylate

4-vinyl-2,6-dimethyldipicolinate