(2E,7E)-(5R,6S)-6-(tert-Butyl-dimethyl-silanyloxy)-5-(4-methoxy-benzyloxy)-8-((S)-4-methyl-3,6-dihydro-2H-pyran-2-yl)-octa-2,7-dienal

Base Information

Chemical Name:(2E,7E)-(5R,6S)-6-(tert-Butyl-dimethyl-silanyloxy)-5-(4-methoxy-benzyloxy)-8-((S)-4-methyl-3,6-dihydro-2H-pyran-2-yl)-octa-2,7-dienal
CAS No.:372511-37-0
Molecular Formula:C₂₈H₄₂O₅Si
Molecular Weight:486.724
Hs Code.:

Synonyms:(2E,7E)-(5R,6S)-6-(tert-Butyl-dimethyl-silanyloxy)-5-(4-methoxy-benzyloxy)-8-((S)-4-methyl-3,6-dihydro-2H-pyran-2-yl)-octa-2,7-dienal

Suppliers and Price of (2E,7E)-(5R,6S)-6-(tert-Butyl-dimethyl-silanyloxy)-5-(4-methoxy-benzyloxy)-8-((S)-4-methyl-3,6-dihydro-2H-pyran-2-yl)-octa-2,7-dienal

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (2E,7E)-(5R,6S)-6-(tert-Butyl-dimethyl-silanyloxy)-5-(4-methoxy-benzyloxy)-8-((S)-4-methyl-3,6-dihydro-2H-pyran-2-yl)-octa-2,7-dienal

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (2E,7E)-(5R,6S)-6-(tert-Butyl-dimethyl-silanyloxy)-5-(4-methoxy-benzyloxy)-8-((S)-4-methyl-3,6-dihydro-2H-pyran-2-yl)-octa-2,7-dienal

There total 20 articles about (2E,7E)-(5R,6S)-6-(tert-Butyl-dimethyl-silanyloxy)-5-(4-methoxy-benzyloxy)-8-((S)-4-methyl-3,6-dihydro-2H-pyran-2-yl)-octa-2,7-dienal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 54717-57-6
1-methoxy-3-methyl-1, 3-butadiene

: 372511-37-0
(2E,7E)-(5R,6S)-6-(tert-Butyl-dimethyl-silanyloxy)-5-(4-methoxy-benzyloxy)-8-((S)-4-methyl-3,6-dihydro-2H-pyran-2-yl)-octa-2,7-dienal

Guidance literature:: Multi-step reaction with 8 steps

1.1: 71 percent / 4 Angstroem molecular sieves / chiral Cr(III) catalyst

2.1: Et₃SiH; BF₃*OEt₂ / CH₂Cl₂

2.2: 72 percent / HCl / CH₂Cl₂; methanol

3.1: 80 percent / (COCl)2; DMSO; Et₃N

4.1: (c-Hex)2BCl; Et₃N / diethyl ether / -78 °C

4.2: H₂o2

4.3: 87 percent / MsCl; Et₃N / CH₂Cl₂

5.1: 100 percent / Zn(BH₄)2 / diethyl ether / -40 °C

6.1: 26-lutidine

7.1: TBAF; AcOH

With 2,6-dimethylpyridine; triethylsilane; zinc(II) tetrahydroborate; oxalyl dichloride; 4 A molecular sieve; boron trifluoride diethyl etherate; dicyclohexylboron chloride; tetrabutyl ammonium fluoride; acetic acid; dimethyl sulfoxide; triethylamine; chiral Cr(III) catalyst; In diethyl ether; dichloromethane; 1.1: hetero-Diels-Alder reaction / 3.1: Swern oxidation / 8.1: Dess-Martin oxidation;
DOI:10.1021/ol010150u

Reference yield:

: 89238-99-3
O-(4-methoxybenzyl)-trichloroacetimidate

: 372511-37-0
(2E,7E)-(5R,6S)-6-(tert-Butyl-dimethyl-silanyloxy)-5-(4-methoxy-benzyloxy)-8-((S)-4-methyl-3,6-dihydro-2H-pyran-2-yl)-octa-2,7-dienal

Guidance literature:: Multi-step reaction with 15 steps

1.1: TfOH / diethyl ether

2.1: LiAlH₄ / tetrahydrofuran

3.1: iPr₂NEt; LiCl / acetonitrile

4.1: DIBAL / CH₂Cl₂ / -78 °C

5.1: imidazole / CH₂Cl₂

6.1: p-TsOH / methanol

7.1: (c-Hex)2BCl; Et₃N / diethyl ether / -78 °C

7.2: H₂o2

7.3: 87 percent / MsCl; Et₃N / CH₂Cl₂

8.1: 100 percent / Zn(BH₄)2 / diethyl ether / -40 °C

9.1: 26-lutidine

10.1: TBAF; AcOH

With 1H-imidazole; 2,6-dimethylpyridine; lithium aluminium tetrahydride; zinc(II) tetrahydroborate; trifluorormethanesulfonic acid; dicyclohexylboron chloride; tetrabutyl ammonium fluoride; diisobutylaluminium hydride; toluene-4-sulfonic acid; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; lithium chloride; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; acetonitrile; 3.1: Dess-Martin oxidation / 4.1: Horner-Wadsworth-Emmons olefination / 8.1: Swern oxidation / 9.1: Grignard reaction / 10.1: Swern oxidation / 15.1: Dess-Martin oxidation;
DOI:10.1021/ol010150u

Reference yield:

: 218898-32-9
(2S)-4-methyl-3,6-dihydro-2H-pyran-2-carbaldehyde

: 372511-37-0
(2E,7E)-(5R,6S)-6-(tert-Butyl-dimethyl-silanyloxy)-5-(4-methoxy-benzyloxy)-8-((S)-4-methyl-3,6-dihydro-2H-pyran-2-yl)-octa-2,7-dienal

Guidance literature:: Multi-step reaction with 5 steps

1.1: (c-Hex)2BCl; Et₃N / diethyl ether / -78 °C

1.2: H₂o2

1.3: 87 percent / MsCl; Et₃N / CH₂Cl₂

2.1: 100 percent / Zn(BH₄)2 / diethyl ether / -40 °C

3.1: 26-lutidine

4.1: TBAF; AcOH

With 2,6-dimethylpyridine; zinc(II) tetrahydroborate; dicyclohexylboron chloride; tetrabutyl ammonium fluoride; acetic acid; triethylamine; In diethyl ether; 5.1: Dess-Martin oxidation;
DOI:10.1021/ol010150u