C₅₃H₅₄N₄O₃

Base Information

Chemical Name:C₅₃H₅₄N₄O₃
CAS No.:1428428-14-1
Molecular Formula:C₅₃H₅₄N₄O₃
Molecular Weight:795.037
Hs Code.:

C<sub>53</sub>H<sub>54</sub>N<sub>4</sub>O<sub>3</sub>

Synonyms:C₅₃H₅₄N₄O₃

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Chemical Property of C₅₃H₅₄N₄O₃

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Technology Process of C₅₃H₅₄N₄O₃

There total 17 articles about C₅₃H₅₄N₄O₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 1428428-13-0
C₅₈H₆₀N₄O₄

: 1428428-14-1
C₅₃H₅₄N₄O₃

Guidance literature:: C₅₈H₆₀N₄O₄; With (carbonyl)(chloro)(hydrido)tris(triphenylphosphine)ruthenium(II); In toluene; for 2h; Reflux; Inert atmosphere;

With 2,6-dimethylpyridine; tert.-butylhydroperoxide; sodium periodate; osmium(VIII) oxide; In 1,4-dioxane; water; tert-butyl alcohol; at 20 ℃; for 5h;

With potassium carbonate; In methanol; at 0 ℃; for 4h; Inert atmosphere;
DOI:10.1021/ol400469w

Reference yield:

: C₃₄H₃₇NO₃Si

: 1428428-14-1
C₅₃H₅₄N₄O₃

Guidance literature:: Multi-step reaction with 12 steps

1.1: tetrahydrofuran / 12 h / Inert atmosphere; Reflux

2.1: lithium borohydride / ethanol / 4 h / Inert atmosphere

3.1: palladium 10% on activated carbon; ammonium formate / methanol / 12.5 h / Inert atmosphere

4.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 16 h / Inert atmosphere

5.1: sodium hydride / N,N-dimethyl-formamide; tetrahydrofuran; mineral oil / 2 h / 0 - 60 °C / Inert atmosphere

6.1: tetrabutyl ammonium fluoride / tetrahydrofuran / Inert atmosphere

7.1: Dess-Martin periodane / dichloromethane / 1 h / 20 °C / Inert atmosphere

8.1: copper(II) sulfate / toluene / 16 h / 20 °C / Inert atmosphere

9.1: N,N,N,N,N,N-hexamethylphosphoric triamide / tetrahydrofuran; chlorobenzene / 0.5 h / 20 - 110 °C / Inert atmosphere

10.1: hydrogenchloride / Inert atmosphere

11.1: N-ethyl-N,N-diisopropylamine; pivaloyl chloride / dichloromethane / 0.5 h / 0 - 20 °C / Inert atmosphere

11.2: 0.5 h / 0 - 20 °C / Inert atmosphere

12.1: (carbonyl)(chloro)(hydrido)tris(triphenylphosphine)ruthenium(II) / toluene / 2 h / Reflux; Inert atmosphere

12.2: 5 h / 20 °C

12.3: 4 h / 0 °C / Inert atmosphere

With hydrogenchloride; N,N,N,N,N,N-hexamethylphosphoric triamide; lithium borohydride; (carbonyl)(chloro)(hydrido)tris(triphenylphosphine)ruthenium(II); palladium 10% on activated carbon; tetrabutyl ammonium fluoride; ammonium formate; pivaloyl chloride; sodium hydride; Dess-Martin periodane; copper(II) sulfate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide; chlorobenzene; toluene; mineral oil; 9.1: |Grignard Reaction;
DOI:10.1021/ol400469w

Reference yield:

: C₃₄H₃₉NO₃Si

: 1428428-14-1
C₅₃H₅₄N₄O₃

Guidance literature:: Multi-step reaction with 13 steps

1.1: Dess-Martin periodane / dichloromethane / 1.5 h / 20 °C / Inert atmosphere

2.1: tetrahydrofuran / 12 h / Inert atmosphere; Reflux

3.1: lithium borohydride / ethanol / 4 h / Inert atmosphere

4.1: palladium 10% on activated carbon; ammonium formate / methanol / 12.5 h / Inert atmosphere

5.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 16 h / Inert atmosphere

6.1: sodium hydride / N,N-dimethyl-formamide; tetrahydrofuran; mineral oil / 2 h / 0 - 60 °C / Inert atmosphere

7.1: tetrabutyl ammonium fluoride / tetrahydrofuran / Inert atmosphere

8.1: Dess-Martin periodane / dichloromethane / 1 h / 20 °C / Inert atmosphere

9.1: copper(II) sulfate / toluene / 16 h / 20 °C / Inert atmosphere

10.1: N,N,N,N,N,N-hexamethylphosphoric triamide / tetrahydrofuran; chlorobenzene / 0.5 h / 20 - 110 °C / Inert atmosphere

11.1: hydrogenchloride / Inert atmosphere

12.1: N-ethyl-N,N-diisopropylamine; pivaloyl chloride / dichloromethane / 0.5 h / 0 - 20 °C / Inert atmosphere

12.2: 0.5 h / 0 - 20 °C / Inert atmosphere

13.1: (carbonyl)(chloro)(hydrido)tris(triphenylphosphine)ruthenium(II) / toluene / 2 h / Reflux; Inert atmosphere

13.2: 5 h / 20 °C

13.3: 4 h / 0 °C / Inert atmosphere

With hydrogenchloride; N,N,N,N,N,N-hexamethylphosphoric triamide; lithium borohydride; (carbonyl)(chloro)(hydrido)tris(triphenylphosphine)ruthenium(II); palladium 10% on activated carbon; tetrabutyl ammonium fluoride; ammonium formate; pivaloyl chloride; sodium hydride; Dess-Martin periodane; copper(II) sulfate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide; chlorobenzene; toluene; mineral oil; 10.1: |Grignard Reaction;
DOI:10.1021/ol400469w