4-hydroxy-9-methyl-6-methylene-3-phenylsulfanyl-methyl-octahydro-azuleno[4,5-b]furan-2,8-dione

Base Information

Chemical Name:4-hydroxy-9-methyl-6-methylene-3-phenylsulfanyl-methyl-octahydro-azuleno[4,5-b]furan-2,8-dione
CAS No.:1311188-77-8
Molecular Formula:C₂₁H₂₄O₄S
Molecular Weight:372.485
Hs Code.:

Synonyms:4-hydroxy-9-methyl-6-methylene-3-phenylsulfanyl-methyl-octahydro-azuleno[4,5-b]furan-2,8-dione

Suppliers and Price of 4-hydroxy-9-methyl-6-methylene-3-phenylsulfanyl-methyl-octahydro-azuleno[4,5-b]furan-2,8-dione

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 4-hydroxy-9-methyl-6-methylene-3-phenylsulfanyl-methyl-octahydro-azuleno[4,5-b]furan-2,8-dione

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 4-hydroxy-9-methyl-6-methylene-3-phenylsulfanyl-methyl-octahydro-azuleno[4,5-b]furan-2,8-dione

There total 15 articles about 4-hydroxy-9-methyl-6-methylene-3-phenylsulfanyl-methyl-octahydro-azuleno[4,5-b]furan-2,8-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₁H₂₄O₄S

: 1311188-77-8
4-hydroxy-9-methyl-6-methylene-3-phenylsulfanyl-methyl-octahydro-azuleno[4,5-b]furan-2,8-dione

Guidance literature:: With titanium(IV) dichlorodiisopropylate; In dichloromethane; at -18 ℃; for 5h;
DOI:10.1021/ol201322w

Reference yield:

: 1311188-71-2
4-hydroxymethyl-5-(5-isopropenyl-2-methyl-3-oxo-cyclopentyl)-3-methylene-dihydro-furan-2-one

: 1311188-77-8
4-hydroxy-9-methyl-6-methylene-3-phenylsulfanyl-methyl-octahydro-azuleno[4,5-b]furan-2,8-dione

Guidance literature:: Multi-step reaction with 3 steps

1.1: dmap / dichloromethane / 3 h / 20 °C / Cooling with ice

2.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 3.5 h / -78 °C

2.2: 20 °C

3.1: titanium(IV) dichlorodiisopropylate / dichloromethane / 5 h / -18 °C

With dmap; titanium(IV) dichlorodiisopropylate; oxalyl dichloride; dimethyl sulfoxide; In dichloromethane; 2.1: Swern oxidation / 2.2: Swern oxidation;
DOI:10.1021/ol201322w

Reference yield:

: 1311188-75-6
4-hydroxymethyl-5-(5-isopropenyl-2-methyl-3-oxo-cyclopentyl)-3-phenoxymethyl-dihydro-furan-2-one

: 1311188-77-8
4-hydroxy-9-methyl-6-methylene-3-phenylsulfanyl-methyl-octahydro-azuleno[4,5-b]furan-2,8-dione

Guidance literature:: Multi-step reaction with 2 steps

1.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 3.5 h / -78 °C

1.2: 20 °C

2.1: titanium(IV) dichlorodiisopropylate / dichloromethane / 5 h / -18 °C

With titanium(IV) dichlorodiisopropylate; oxalyl dichloride; dimethyl sulfoxide; In dichloromethane; 1.1: Swern oxidation / 1.2: Swern oxidation;
DOI:10.1021/ol201322w