(R)-tert-butyl 3-(5'-chloro-6-fluoro-2,4'-bipyridin-2'-ylcarbamoyl)piperidine-1-carboxylate

Base Information

Chemical Name:(R)-tert-butyl 3-(5'-chloro-6-fluoro-2,4'-bipyridin-2'-ylcarbamoyl)piperidine-1-carboxylate
CAS No.:1270077-44-5
Molecular Formula:C₂₁H₂₄ClFN₄O₃
Molecular Weight:434.898
Hs Code.:

Synonyms:(R)-tert-butyl 3-(5'-chloro-6-fluoro-2,4'-bipyridin-2'-ylcarbamoyl)piperidine-1-carboxylate

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Chemical Property of (R)-tert-butyl 3-(5'-chloro-6-fluoro-2,4'-bipyridin-2'-ylcarbamoyl)piperidine-1-carboxylate

Chemical Property:

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Technology Process of (R)-tert-butyl 3-(5'-chloro-6-fluoro-2,4'-bipyridin-2'-ylcarbamoyl)piperidine-1-carboxylate

There total 1 articles about (R)-tert-butyl 3-(5'-chloro-6-fluoro-2,4'-bipyridin-2'-ylcarbamoyl)piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 659731-48-3
5-chloro-2-fluoro-4-iodopyridine

: 1270077-44-5
(R)-tert-butyl 3-(5'-chloro-6-fluoro-2,4'-bipyridin-2'-ylcarbamoyl)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: ammonium hydroxide / water; dimethyl sulfoxide / 18 h / 90 °C

2.1: 1-chloro-1-(dimethylamino)-2-methyl-1-propene / dichloromethane / 0.5 h / 0 - 20 °C

2.2: 2 h / 20 °C

3.1: sodium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,2-dimethoxyethane; water / 1.5 h / 95 °C

With ammonium hydroxide; 1-chloro-1-(dimethylamino)-2-methyl-1-propene; sodium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,2-dimethoxyethane; dichloromethane; water; dimethyl sulfoxide;

Reference yield:

: 1270077-44-5
(R)-tert-butyl 3-(5'-chloro-6-fluoro-2,4'-bipyridin-2'-ylcarbamoyl)piperidine-1-carboxylate

: 3218-02-8
cyclohexylmethylamine

: 1270077-79-6
(R)-3-[5'-chloro-6-(cyclohexylmethylamino)-[2,4,]bipyridinyl-2'-ylcarbamoyl]piperidine-1-carboxylic acid tert-butyl ester

Guidance literature:: In dimethyl sulfoxide; at 95 - 100 ℃; for 20h;

Reference yield:

: 1270077-44-5
(R)-tert-butyl 3-(5'-chloro-6-fluoro-2,4'-bipyridin-2'-ylcarbamoyl)piperidine-1-carboxylate

: 3218-02-8
cyclohexylmethylamine

: (R)-piperidine-3-carboxylic acid [5'-chloro-6-(cyclohexylmethylamino)-[2,4']bipyridinyl-2'-yl]amide trifluoroacetate

Guidance literature:: Multi-step reaction with 2 steps

1: dimethyl sulfoxide / 20 h / 95 - 100 °C

2: hydrogenchloride / 1,4-dioxane; methanol / 1 h / 20 °C

With hydrogenchloride; In 1,4-dioxane; methanol; dimethyl sulfoxide;