5'-O-dimethoxytrityl-N²-isobutyryl-O⁶-<2-(p-nitrophenyl)ethyl>-2'-deoxyguanosine

Base Information

• Chemical Name: 5'-O-dimethoxytrityl-N²-isobutyryl-O⁶-<2-(p-nitrophenyl)ethyl>-2'-deoxyguanosine
• CAS No.: 90678-72-1
• Molecular Formula: C₄₃H₄₄N₆O₉
• Molecular Weight: 788.857

Synonyms:5'-O-dimethoxytrityl-N²-isobutyryl-O⁶-<2-(p-nitrophenyl)ethyl>-2'-deoxyguanosine

Chemical Property of 5'-O-dimethoxytrityl-N²-isobutyryl-O⁶-<2-(p-nitrophenyl)ethyl>-2'-deoxyguanosine

Chemical Property:

Purity/Quality:

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Technology Process of 5'-O-dimethoxytrityl-N²-isobutyryl-O⁶-<2-(p-nitrophenyl)ethyl>-2'-deoxyguanosine

There total 8 articles about 5'-O-dimethoxytrityl-N²-isobutyryl-O⁶-<2-(p-nitrophenyl)ethyl>-2'-deoxyguanosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

4-Oxo-pentanoic acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-{2-isobutyrylamino-6-[2-(4-nitro-phenyl)-ethoxy]-purin-9-yl}-tetrahydro-furan-3-yl ester (86702-72-9) → 5'-O-dimethoxytrityl-N2-isobutyryl-O6-<2-(p-nitrophenyl)ethyl>-2'-deoxyguanosine (90678-72-1)

Guidance literature:

With hydrazine hydrate; In pyridine; acetic acid; for 0.5h;

DOI:10.1016/0040-4020(84)85098-X

Reference yield: 90.0%

4,4'-dimethoxytrityl chloride (40615-36-9) + N2-isobutyryl-O6-<2-(p-nitrophenyl)ethyl>-2'-deoxyguanosine (82921-57-1) → 5'-O-dimethoxytrityl-N2-isobutyryl-O6-<2-(p-nitrophenyl)ethyl>-2'-deoxyguanosine (90678-72-1)

Guidance literature:

With dmap; triethylamine; In pyridine; for 4h;

DOI:10.1021/jo00355a038

Reference yield:

Acetic acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-{2-isobutyrylamino-6-[2-(4-nitro-phenyl)-ethoxy]-purin-9-yl}-tetrahydro-furan-3-yl ester (93130-37-1) → 5'-O-dimethoxytrityl-N2-isobutyryl-O6-<2-(p-nitrophenyl)ethyl>-2'-deoxyguanosine (90678-72-1)

Guidance literature:

With ammonium hydroxide; In 1,4-dioxane; at 20 ℃; for 72h;

DOI:10.1002/hlca.19840670521

upstream raw materials:

4,4'-dimethoxytrityl chloride

N²-isobutyryl-O⁶-<2-(p-nitrophenyl)ethyl>-2'-deoxyguanosine

4-Oxo-pentanoic acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-{2-isobutyrylamino-6-[2-(4-nitro-phenyl)-ethoxy]-purin-9-yl}-tetrahydro-furan-3-yl ester

Acetic acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-{2-isobutyrylamino-6-[2-(4-nitro-phenyl)-ethoxy]-purin-9-yl}-tetrahydro-furan-3-yl ester

Downstream raw materials:

2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-N²-isobutyryl-O⁶-[2-(4-nitrophenyl)ethyl]guanosine 3'-(2-cyanoethyl diisopropylphosphoramidite)

5'-O-dimethoxytrityl-N²-isobutyryl-O⁶-<2-(p-nitrophenyl)ethyl>-2'-deoxyguanosine 3'-(2-chlorophenyl,2-cyanoethyl)phosphate

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