2-(3-{[(5-methoxy-1,3-benzothiazol-2-yl)methyl]amino}-1,2,4-triazin-5-yl)-3-methylphenol

Base Information

Chemical Name:2-(3-{[(5-methoxy-1,3-benzothiazol-2-yl)methyl]amino}-1,2,4-triazin-5-yl)-3-methylphenol
CAS No.:1203604-11-8
Molecular Formula:C₁₉H₁₇N₅O₂S
Molecular Weight:379.442
Hs Code.:

Synonyms:2-(3-{[(5-methoxy-1,3-benzothiazol-2-yl)methyl]amino}-1,2,4-triazin-5-yl)-3-methylphenol

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Chemical Property of 2-(3-{[(5-methoxy-1,3-benzothiazol-2-yl)methyl]amino}-1,2,4-triazin-5-yl)-3-methylphenol

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Technology Process of 2-(3-{[(5-methoxy-1,3-benzothiazol-2-yl)methyl]amino}-1,2,4-triazin-5-yl)-3-methylphenol

There total 9 articles about 2-(3-{[(5-methoxy-1,3-benzothiazol-2-yl)methyl]amino}-1,2,4-triazin-5-yl)-3-methylphenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.0%

: 933738-01-3
(5-methoxy-1,3-benzothiazol-2-yl)methylamine

: 1203605-17-7
2-(3-chloro-1,2,4-triazin-5-yl)-3-methylphenol

: 1203604-11-8
2-(3-{[(5-methoxy-1,3-benzothiazol-2-yl)methyl]amino}-1,2,4-triazin-5-yl)-3-methylphenol

Guidance literature:: In acetonitrile; at 85 ℃; for 48h;

Reference yield: 38.0%

: 1203605-17-7
2-(3-chloro-1,2,4-triazin-5-yl)-3-methylphenol

: 1204196-92-8
(5-methoxybenzothiazol-2-yl)methylamine hydrogen chloride

: 1203604-11-8
2-(3-{[(5-methoxy-1,3-benzothiazol-2-yl)methyl]amino}-1,2,4-triazin-5-yl)-3-methylphenol

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In acetonitrile; at 85 ℃; for 48h; Inert atmosphere;
DOI:10.1021/jm301499r

Reference yield:

: 854059-90-8
5-methoxybenzothiazole-2-carboxaldehyde

: 1203604-11-8
2-(3-{[(5-methoxy-1,3-benzothiazol-2-yl)methyl]amino}-1,2,4-triazin-5-yl)-3-methylphenol

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium methylate; hydroxylamine hydrochloride / ethanol / 20 °C / Inert atmosphere

2.1: acetic acid; zinc / 3 h / 20 °C / Inert atmosphere

2.2: Inert atmosphere

3.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 48 h / 85 °C / Inert atmosphere

With hydroxylamine hydrochloride; sodium methylate; acetic acid; N-ethyl-N,N-diisopropylamine; zinc; In ethanol; acetonitrile;
DOI:10.1021/jm301499r