(E)-5-(4-chloro-3-(2,2,2-trifluoroethoxy)phenyl)-N-(1-(dimethylamino)ethylidene)-7-oxo-4,7-dihydropyrazolo[1,5-a]pyrimidine-3-carboxamide

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Chemical Name:(E)-5-(4-chloro-3-(2,2,2-trifluoroethoxy)phenyl)-N-(1-(dimethylamino)ethylidene)-7-oxo-4,7-dihydropyrazolo[1,5-a]pyrimidine-3-carboxamide
CAS No.:1607024-92-9
Molecular Formula:C₁₉H₁₇ClF₃N₅O₃
Molecular Weight:455.824
Hs Code.:

Synonyms:(E)-5-(4-chloro-3-(2,2,2-trifluoroethoxy)phenyl)-N-(1-(dimethylamino)ethylidene)-7-oxo-4,7-dihydropyrazolo[1,5-a]pyrimidine-3-carboxamide

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Chemical Property of (E)-5-(4-chloro-3-(2,2,2-trifluoroethoxy)phenyl)-N-(1-(dimethylamino)ethylidene)-7-oxo-4,7-dihydropyrazolo[1,5-a]pyrimidine-3-carboxamide

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Technology Process of (E)-5-(4-chloro-3-(2,2,2-trifluoroethoxy)phenyl)-N-(1-(dimethylamino)ethylidene)-7-oxo-4,7-dihydropyrazolo[1,5-a]pyrimidine-3-carboxamide

There total 7 articles about (E)-5-(4-chloro-3-(2,2,2-trifluoroethoxy)phenyl)-N-(1-(dimethylamino)ethylidene)-7-oxo-4,7-dihydropyrazolo[1,5-a]pyrimidine-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 18871-66-4
N,N-dimethylacetamide dimethyl acetal

: 1607024-91-8
5-[4-chloro-3-(2,2,2-trifluoroethoxy)phenyl]-7-oxo-4H,7H-pyrazolo[1,5-a]pyrimidine-3-carboxamide

: 1607024-92-9
(E)-5-(4-chloro-3-(2,2,2-trifluoroethoxy)phenyl)-N-(1-(dimethylamino)ethylidene)-7-oxo-4,7-dihydropyrazolo[1,5-a]pyrimidine-3-carboxamide

Guidance literature:: In N,N-dimethyl-formamide; at 120 ℃; for 3h;

Reference yield:

: 1607024-32-7
methyl 4-chloro-3-(2,2,2-trifluoroethoxy)benzoate

: 1607024-92-9
(E)-5-(4-chloro-3-(2,2,2-trifluoroethoxy)phenyl)-N-(1-(dimethylamino)ethylidene)-7-oxo-4,7-dihydropyrazolo[1,5-a]pyrimidine-3-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydroxide; water / methanol / 3 h / 20 °C

2.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 2 h / 20 °C

2.2: 2 h / 20 °C

3.1: toluene-4-sulfonic acid / butan-1-ol / 2 h / Reflux

4.1: potassium carbonate; dihydrogen peroxide / dimethyl sulfoxide; methanol / 2 h / 50 °C

5.1: N,N-dimethyl-formamide / 3 h / 120 °C

With water; dihydrogen peroxide; potassium carbonate; toluene-4-sulfonic acid; 1,1'-carbonyldiimidazole; sodium hydroxide; In tetrahydrofuran; methanol; dimethyl sulfoxide; N,N-dimethyl-formamide; butan-1-ol;

Reference yield:

: 166272-81-7
4-Chloro-3-hydroxy-benzoic acid methyl ester

: 1607024-92-9
(E)-5-(4-chloro-3-(2,2,2-trifluoroethoxy)phenyl)-N-(1-(dimethylamino)ethylidene)-7-oxo-4,7-dihydropyrazolo[1,5-a]pyrimidine-3-carboxamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium hydrogencarbonate / acetone / 0.5 h / 70 °C

1.2: 70 °C

2.1: sodium hydroxide; water / methanol / 3 h / 20 °C

3.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 2 h / 20 °C

3.2: 2 h / 20 °C

4.1: toluene-4-sulfonic acid / butan-1-ol / 2 h / Reflux

5.1: potassium carbonate; dihydrogen peroxide / dimethyl sulfoxide; methanol / 2 h / 50 °C

6.1: N,N-dimethyl-formamide / 3 h / 120 °C

With water; dihydrogen peroxide; potassium carbonate; potassium hydrogencarbonate; toluene-4-sulfonic acid; 1,1'-carbonyldiimidazole; sodium hydroxide; In tetrahydrofuran; methanol; dimethyl sulfoxide; N,N-dimethyl-formamide; acetone; butan-1-ol;