5-chloro-6'-[2-fluoro-4-(trifluoromethyl)phenyl]-2-(hydroxymethyl)-6-methyl-3,3'-bipyridin-4(1H)-one

Base Information

Chemical Name:5-chloro-6'-[2-fluoro-4-(trifluoromethyl)phenyl]-2-(hydroxymethyl)-6-methyl-3,3'-bipyridin-4(1H)-one
CAS No.:1257875-11-8
Molecular Formula:C₁₉H₁₃ClF₄N₂O₂
Molecular Weight:412.771
Hs Code.:

Synonyms:5-chloro-6'-[2-fluoro-4-(trifluoromethyl)phenyl]-2-(hydroxymethyl)-6-methyl-3,3'-bipyridin-4(1H)-one

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Chemical Property of 5-chloro-6'-[2-fluoro-4-(trifluoromethyl)phenyl]-2-(hydroxymethyl)-6-methyl-3,3'-bipyridin-4(1H)-one

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Technology Process of 5-chloro-6'-[2-fluoro-4-(trifluoromethyl)phenyl]-2-(hydroxymethyl)-6-methyl-3,3'-bipyridin-4(1H)-one

There total 11 articles about 5-chloro-6'-[2-fluoro-4-(trifluoromethyl)phenyl]-2-(hydroxymethyl)-6-methyl-3,3'-bipyridin-4(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 6'-[2-fluoro-4-(trifluoromethyl)phenyl]-2-(hydroxymethyl)-6-methyl-3,3'-bipyridin-4(1H)-one

: 1257875-11-8
5-chloro-6'-[2-fluoro-4-(trifluoromethyl)phenyl]-2-(hydroxymethyl)-6-methyl-3,3'-bipyridin-4(1H)-one

Guidance literature:: With trichloroisocyanuric acid; In methanol; dichloromethane; at 0 - 20 ℃; for 2.5h; Product distribution / selectivity; Inert atmosphere;

Reference yield:

: 1257875-17-4
{6-[2-fluoro-4-(trifluoromethyl)phenyl]-3-pyridinyl}boronic acid

: 1257875-11-8
5-chloro-6'-[2-fluoro-4-(trifluoromethyl)phenyl]-2-(hydroxymethyl)-6-methyl-3,3'-bipyridin-4(1H)-one

Guidance literature:: Multi-step reaction with 3 steps

1: bis-triphenylphosphine-palladium(II) chloride; sodium carbonate / water; toluene; ethanol / 3 h / 80 °C / Inert atmosphere

2: ammonium hydroxide / ethanol / 0.83 h / 140 °C / Sealed tube; Microwave irradiation

3: trichloroisocyanuric acid / methanol; dichloromethane / 1 h / 0 °C

With bis-triphenylphosphine-palladium(II) chloride; ammonium hydroxide; trichloroisocyanuric acid; sodium carbonate; In methanol; ethanol; dichloromethane; water; toluene; 1: |Suzuki Coupling;
DOI:10.1021/acs.jmedchem.7b01256

Reference yield:

: 1257875-16-3
5-bromo-2-[2-fluoro-4-(trifluoromethyl)phenyl]pyridine

: 1257875-11-8
5-chloro-6'-[2-fluoro-4-(trifluoromethyl)phenyl]-2-(hydroxymethyl)-6-methyl-3,3'-bipyridin-4(1H)-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: bis-triphenylphosphine-palladium(II) chloride; potassium acetate / 1,4-dioxane / 5 h / 100 °C / Inert atmosphere

1.2: 20 °C

2.1: bis-triphenylphosphine-palladium(II) chloride; sodium carbonate / water; toluene; ethanol / 3 h / 80 °C / Inert atmosphere

3.1: ammonium hydroxide / ethanol / 0.83 h / 140 °C / Sealed tube; Microwave irradiation

4.1: trichloroisocyanuric acid / methanol; dichloromethane / 1 h / 0 °C

With bis-triphenylphosphine-palladium(II) chloride; ammonium hydroxide; trichloroisocyanuric acid; potassium acetate; sodium carbonate; In 1,4-dioxane; methanol; ethanol; dichloromethane; water; toluene; 2.1: |Suzuki Coupling;
DOI:10.1021/acs.jmedchem.7b01256