(R,S)-3-methoxy-4-<<1-methyl-5-<(2-methyl-4,4,4-trifluorobutyl)carbamoyl>indol-3-yl>methyl>benzoic acid

Base Information

Chemical Name:(R,S)-3-methoxy-4-<<1-methyl-5-<(2-methyl-4,4,4-trifluorobutyl)carbamoyl>indol-3-yl>methyl>benzoic acid
CAS No.:136564-75-5
Molecular Formula:C₂₄H₂₅F₃N₂O₄
Molecular Weight:462.469
Hs Code.:

Synonyms:(R,S)-3-methoxy-4-<<1-methyl-5-<(2-methyl-4,4,4-trifluorobutyl)carbamoyl>indol-3-yl>methyl>benzoic acid

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Chemical Property of (R,S)-3-methoxy-4-<<1-methyl-5-<(2-methyl-4,4,4-trifluorobutyl)carbamoyl>indol-3-yl>methyl>benzoic acid

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Technology Process of (R,S)-3-methoxy-4-<<1-methyl-5-<(2-methyl-4,4,4-trifluorobutyl)carbamoyl>indol-3-yl>methyl>benzoic acid

There total 6 articles about (R,S)-3-methoxy-4-<<1-methyl-5-<(2-methyl-4,4,4-trifluorobutyl)carbamoyl>indol-3-yl>methyl>benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 136564-74-4
methyl (R,S)-3-methoxy-4-<<1-methyl-5-<(2-methyl-4,4,4-trifluorobutyl)carbamoyl>indol-3-yl>methyl>benzoate

: 136564-75-5
(R,S)-3-methoxy-4-<<1-methyl-5-<(2-methyl-4,4,4-trifluorobutyl)carbamoyl>indol-3-yl>methyl>benzoic acid

Guidance literature:: With lithium hydroxide; In tetrahydrofuran; methanol; for 18h; Ambient temperature;
DOI:10.1021/jm00035a008

Reference yield:

: 136564-73-3
methyl 4-<<5-carboxy-1-methylindol-3-yl>methyl>-3-methoxybenzoate

: 136564-75-5
(R,S)-3-methoxy-4-<<1-methyl-5-<(2-methyl-4,4,4-trifluorobutyl)carbamoyl>indol-3-yl>methyl>benzoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 63 percent / 1-<3-(dimethylamino)propyl>-3-ethylcarbodiimide, 4-(dimethylamino)pyridine / CH₂Cl₂ / 18 h / Ambient temperature

2: 88 percent / lithium hydroxide monohydrate / tetrahydrofuran; methanol / 18 h / Ambient temperature

With dmap; lithium hydroxide; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1021/jm00035a008

Reference yield:

: 99783-23-0
4,4,4-trifluoro-2-methylbutanoic acid

: 136564-75-5
(R,S)-3-methoxy-4-<<1-methyl-5-<(2-methyl-4,4,4-trifluorobutyl)carbamoyl>indol-3-yl>methyl>benzoic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) 1,1'-carbonyldiimidazole, 2.) ammonia / 1.) CH₂Cl₂, reflux, 30 min, 2.) CH₂Cl₂, RT, 18 h

2: 88 percent / lithium aluminum hydride / diethyl ether / 12 h / Heating

3: 63 percent / 1-<3-(dimethylamino)propyl>-3-ethylcarbodiimide, 4-(dimethylamino)pyridine / CH₂Cl₂ / 18 h / Ambient temperature

4: 88 percent / lithium hydroxide monohydrate / tetrahydrofuran; methanol / 18 h / Ambient temperature

With dmap; lithium hydroxide; lithium aluminium tetrahydride; ammonia; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; 1,1'-carbonyldiimidazole; In tetrahydrofuran; methanol; diethyl ether; dichloromethane;
DOI:10.1021/jm00035a008