3-Benzyloxycarbonylamino-propionic acid 2-trimethylsilanyl-ethyl ester

Base Information

• Chemical Name: 3-Benzyloxycarbonylamino-propionic acid 2-trimethylsilanyl-ethyl ester
• CAS No.: 512178-52-8
• Molecular Formula: C₁₆H₂₅NO₄Si
• Molecular Weight: 323.464
• Mol file: 512178-52-8.mol

Synonyms:3-Benzyloxycarbonylamino-propionic acid 2-trimethylsilanyl-ethyl ester

Chemical Property of 3-Benzyloxycarbonylamino-propionic acid 2-trimethylsilanyl-ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-Benzyloxycarbonylamino-propionic acid 2-trimethylsilanyl-ethyl ester

There total 2 articles about 3-Benzyloxycarbonylamino-propionic acid 2-trimethylsilanyl-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-(Trimethylsilyl)ethanol (2916-68-9) + 3-(benzyloxycarbonylamino)propanoic acid (2304-94-1) → 3-Benzyloxycarbonylamino-propionic acid 2-trimethylsilanyl-ethyl ester (512178-52-8)

Guidance literature:

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 0 - 20 ℃; for 5h; Inert atmosphere;

DOI:10.1021/jo402437z

Reference yield:

benzyl chloroformate (501-53-1,94274-21-2) → 3-Benzyloxycarbonylamino-propionic acid 2-trimethylsilanyl-ethyl ester (512178-52-8)

Guidance literature:

Multi-step reaction with 2 steps

1: NaOH

2: DCC, DMAP / CH₂Cl₂

With dmap; sodium hydroxide; dicyclohexyl-carbodiimide; In dichloromethane;

DOI:10.1248/cpb.42.2394

Reference yield:

3-Benzyloxycarbonylamino-propionic acid 2-trimethylsilanyl-ethyl ester (512178-52-8) → 3-[(R)-2-Amino-3-(4-methoxy-phenyl)-propionylamino]-propionic acid 2-trimethylsilanyl-ethyl ester (1026148-52-6)

Guidance literature:

Multi-step reaction with 3 steps

1: H₂, HCOOH / Pd/C / methanol

2: 82 percent / diethyl phosphorocyanide, Et₃N / dimethylformamide

3: H₂, HCOOH / Pd/C / methanol

With formic acid; diethyl cyanophosphonate; hydrogen; triethylamine; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide;

DOI:10.1248/cpb.42.2394

upstream raw materials:

2-(Trimethylsilyl)ethanol

3-(benzyloxycarbonylamino)propanoic acid

benzyl chloroformate

Downstream raw materials:

3-[(R)-2-Amino-3-(4-methoxy-phenyl)-propionylamino]-propionic acid 2-trimethylsilanyl-ethyl ester

3-[(R)-2-[2-(Diethoxy-phosphoryl)-acetylamino]-3-(4-methoxy-phenyl)-propionylamino]-propionic acid 2-trimethylsilanyl-ethyl ester

3-[(R)-2-Benzyloxycarbonylamino-3-(4-methoxy-phenyl)-propionylamino]-propionic acid 2-trimethylsilanyl-ethyl ester