3-(4-(((6-(1,1-dimethylethyl)-2'-fluoro-5'-(methyloxy)-1,1'-biphenyl-3-yl)methyl)oxy)phenyl)-2,2-dimethylpropanoic acid

Base Information

Chemical Name:3-(4-(((6-(1,1-dimethylethyl)-2'-fluoro-5'-(methyloxy)-1,1'-biphenyl-3-yl)methyl)oxy)phenyl)-2,2-dimethylpropanoic acid
CAS No.:1073544-01-0
Molecular Formula:C₂₉H₃₃FO₄
Molecular Weight:464.577
Hs Code.:

Synonyms:3-(4-(((6-(1,1-dimethylethyl)-2'-fluoro-5'-(methyloxy)-1,1'-biphenyl-3-yl)methyl)oxy)phenyl)-2,2-dimethylpropanoic acid

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Chemical Property of 3-(4-(((6-(1,1-dimethylethyl)-2'-fluoro-5'-(methyloxy)-1,1'-biphenyl-3-yl)methyl)oxy)phenyl)-2,2-dimethylpropanoic acid

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Technology Process of 3-(4-(((6-(1,1-dimethylethyl)-2'-fluoro-5'-(methyloxy)-1,1'-biphenyl-3-yl)methyl)oxy)phenyl)-2,2-dimethylpropanoic acid

There total 7 articles about 3-(4-(((6-(1,1-dimethylethyl)-2'-fluoro-5'-(methyloxy)-1,1'-biphenyl-3-yl)methyl)oxy)phenyl)-2,2-dimethylpropanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₃₀H₃₅FO₄

: 1073544-01-0
3-(4-(((6-(1,1-dimethylethyl)-2'-fluoro-5'-(methyloxy)-1,1'-biphenyl-3-yl)methyl)oxy)phenyl)-2,2-dimethylpropanoic acid

Guidance literature:: With lithium hydroxide; water; In dimethyl sulfoxide; at 20 ℃; for 16h;

Reference yield:

: 951124-27-9
methyl 2,2-dimethyl-3-(4-((phenylmethyl)oxy)phenyl)propanoate

: 1073544-01-0
3-(4-(((6-(1,1-dimethylethyl)-2'-fluoro-5'-(methyloxy)-1,1'-biphenyl-3-yl)methyl)oxy)phenyl)-2,2-dimethylpropanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogen / palladium on activated carbon / methanol / 16 h / 20 °C

2: caesium carbonate / dimethyl sulfoxide / 16 h / 20 °C

3: lithium hydroxide; water / dimethyl sulfoxide / 16 h / 20 °C

With lithium hydroxide; water; hydrogen; caesium carbonate; palladium on activated carbon; In methanol; dimethyl sulfoxide;

Reference yield:

: 14034-08-3
methyl 3-bromo-4-(tert-butyl)benzoate

: 1073544-01-0
3-(4-(((6-(1,1-dimethylethyl)-2'-fluoro-5'-(methyloxy)-1,1'-biphenyl-3-yl)methyl)oxy)phenyl)-2,2-dimethylpropanoic acid

Guidance literature:: Multi-step reaction with 5 steps

1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide; toluene / 21 h / 100 °C

2: lithium aluminium tetrahydride / tetrahydrofuran / 0.25 h / 0 °C

3: thionyl chloride / dichloromethane / 16 h / 23 °C

4: caesium carbonate / dimethyl sulfoxide / 16 h / 20 °C

5: lithium hydroxide; water / dimethyl sulfoxide / 16 h / 20 °C

With lithium hydroxide; lithium aluminium tetrahydride; thionyl chloride; water; potassium carbonate; caesium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene;