ethyl 3-((2S,4R,6S)-4-phenyl-6-((triphenylsilyl)methyl)tetrahydro-2H-pyran-2-yl)propanoate

Base Information

Chemical Name:ethyl 3-((2S,4R,6S)-4-phenyl-6-((triphenylsilyl)methyl)tetrahydro-2H-pyran-2-yl)propanoate
CAS No.:1620650-32-9
Molecular Formula:C₃₅H₃₈O₃Si
Molecular Weight:534.77
Hs Code.:

Synonyms:ethyl 3-((2S,4R,6S)-4-phenyl-6-((triphenylsilyl)methyl)tetrahydro-2H-pyran-2-yl)propanoate

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Chemical Property of ethyl 3-((2S,4R,6S)-4-phenyl-6-((triphenylsilyl)methyl)tetrahydro-2H-pyran-2-yl)propanoate

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Technology Process of ethyl 3-((2S,4R,6S)-4-phenyl-6-((triphenylsilyl)methyl)tetrahydro-2H-pyran-2-yl)propanoate

There total 7 articles about ethyl 3-((2S,4R,6S)-4-phenyl-6-((triphenylsilyl)methyl)tetrahydro-2H-pyran-2-yl)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: C₃₅H₃₆O₃Si

: 1620650-32-9
ethyl 3-((2S,4R,6S)-4-phenyl-6-((triphenylsilyl)methyl)tetrahydro-2H-pyran-2-yl)propanoate

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In ethyl acetate; at 50 ℃; for 48h;
DOI:10.1002/anie.201402934

Reference yield:

: 1643592-35-1
C₃₁H₃₀O₂Si

: 1620650-32-9
ethyl 3-((2S,4R,6S)-4-phenyl-6-((triphenylsilyl)methyl)tetrahydro-2H-pyran-2-yl)propanoate

Guidance literature:: Multi-step reaction with 3 steps

1: Dess-Martin periodane / dichloromethane / 4 h / 0 °C / Inert atmosphere

2: tetrahydrofuran / 22 h / 20 °C / Inert atmosphere

3: palladium 10% on activated carbon; hydrogen / ethyl acetate / 48 h / 50 °C

With palladium 10% on activated carbon; hydrogen; Dess-Martin periodane; In tetrahydrofuran; dichloromethane; ethyl acetate; 1: |Dess-Martin Oxidation / 2: |Wittig Olefination;
DOI:10.1002/anie.201402934

Reference yield:

: 1620650-79-4
(2S,4S)-2,2,4,4-tetramethylpentan-3-yl 4-phenyl-2-(triphenylsilylmethyl)-3,4-dihydro-2H-pyran-6-carboxylate

: 1620650-32-9
ethyl 3-((2S,4R,6S)-4-phenyl-6-((triphenylsilyl)methyl)tetrahydro-2H-pyran-2-yl)propanoate

Guidance literature:: Multi-step reaction with 4 steps

1: lithium aluminium tetrahydride / tetrahydrofuran / 7 h / 0 - 20 °C / Inert atmosphere

2: Dess-Martin periodane / dichloromethane / 4 h / 0 °C / Inert atmosphere

3: tetrahydrofuran / 22 h / 20 °C / Inert atmosphere

4: palladium 10% on activated carbon; hydrogen / ethyl acetate / 48 h / 50 °C

With lithium aluminium tetrahydride; palladium 10% on activated carbon; hydrogen; Dess-Martin periodane; In tetrahydrofuran; dichloromethane; ethyl acetate; 2: |Dess-Martin Oxidation / 3: |Wittig Olefination;
DOI:10.1002/anie.201402934