4-(4-chlorophenyl)-2-ethoxymethyleneamino-5-hydroxy-8-methoxy-4H-pyrano[3,2-c]quinoline-3-carbonitrile

Base Information

• Chemical Name: 4-(4-chlorophenyl)-2-ethoxymethyleneamino-5-hydroxy-8-methoxy-4H-pyrano[3,2-c]quinoline-3-carbonitrile
• CAS No.: 1203608-21-2
• Molecular Formula: C₂₃H₁₈ClN₃O₄
• Molecular Weight: 435.867

Synonyms:4-(4-chlorophenyl)-2-ethoxymethyleneamino-5-hydroxy-8-methoxy-4H-pyrano[3,2-c]quinoline-3-carbonitrile

Chemical Property of 4-(4-chlorophenyl)-2-ethoxymethyleneamino-5-hydroxy-8-methoxy-4H-pyrano[3,2-c]quinoline-3-carbonitrile

Chemical Property:

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Technology Process of 4-(4-chlorophenyl)-2-ethoxymethyleneamino-5-hydroxy-8-methoxy-4H-pyrano[3,2-c]quinoline-3-carbonitrile

There total 1 articles about 4-(4-chlorophenyl)-2-ethoxymethyleneamino-5-hydroxy-8-methoxy-4H-pyrano[3,2-c]quinoline-3-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

2-amino-4-(4-chlorophenyl)-5-hydroxy-8-methoxy-4H-pyrano[3,2-c]quinoline-3-carbonitrile (1203608-17-6) + orthoformic acid triethyl ester (122-51-0) → 4-(4-chlorophenyl)-2-ethoxymethyleneamino-5-hydroxy-8-methoxy-4H-pyrano[3,2-c]quinoline-3-carbonitrile (1203608-21-2)

Guidance literature:

for 5h; Reflux;

DOI:10.3184/030823409X12509546260155

Reference yield: 89.0%

4-(4-chlorophenyl)-2-ethoxymethyleneamino-5-hydroxy-8-methoxy-4H-pyrano[3,2-c]quinoline-3-carbonitrile (1203608-21-2) → 8-amino-7-(4-chlorophenyl)-6-hydroxy-3-methoxy-7H-pyrimido[5',4':5,6]pyrano[3,2-c]quinoline (1203608-22-3)

Guidance literature:

With ammonia; In methanol; at 20 ℃; for 1h;

DOI:10.3184/030823409X12509546260155

Reference yield: 85.0%

4-(4-chlorophenyl)-2-ethoxymethyleneamino-5-hydroxy-8-methoxy-4H-pyrano[3,2-c]quinoline-3-carbonitrile (1203608-21-2) → 9-amino-7-(4-chlorophenyl)-6-hydroxy-3-methoxy-8-imino-8,9-dihydro-7H-pyrimido[5',4':5,6]pyrano[3,2-c]quinoline (1203608-23-4)

Guidance literature:

With hydrazine hydrate; In ethanol; at 20 ℃; for 1h;

DOI:10.3184/030823409X12509546260155

upstream raw materials:

2-amino-4-(4-chlorophenyl)-5-hydroxy-8-methoxy-4H-pyrano[3,2-c]quinoline-3-carbonitrile

orthoformic acid triethyl ester

Downstream raw materials:

8-amino-7-(4-chlorophenyl)-6-hydroxy-3-methoxy-7H-pyrimido[5',4':5,6]pyrano[3,2-c]quinoline

9-amino-7-(4-chlorophenyl)-6-hydroxy-3-methoxy-8-imino-8,9-dihydro-7H-pyrimido[5',4':5,6]pyrano[3,2-c]quinoline

7-(4-chlorophenyl)-6-hydroxy-3-methoxy-8-imino-9-methyl-8,9-dihydro-7H-pyrimido[5',4':5,6]pyrano[3,2-c]quinoline

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