(1R,2S)-2-amino-1-[4-(6-dimethylaminomethylpyridin-3-yl)phenyl]-3-fluoropropan-1-ol

Base Information

Chemical Name:(1R,2S)-2-amino-1-[4-(6-dimethylaminomethylpyridin-3-yl)phenyl]-3-fluoropropan-1-ol
CAS No.:1085159-07-4
Molecular Formula:C₁₇H₂₂FN₃O
Molecular Weight:303.38
Hs Code.:

Synonyms:(1R,2S)-2-amino-1-[4-(6-dimethylaminomethylpyridin-3-yl)phenyl]-3-fluoropropan-1-ol

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Chemical Property of (1R,2S)-2-amino-1-[4-(6-dimethylaminomethylpyridin-3-yl)phenyl]-3-fluoropropan-1-ol

Chemical Property:

Purity/Quality:

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Technology Process of (1R,2S)-2-amino-1-[4-(6-dimethylaminomethylpyridin-3-yl)phenyl]-3-fluoropropan-1-ol

There total 7 articles about (1R,2S)-2-amino-1-[4-(6-dimethylaminomethylpyridin-3-yl)phenyl]-3-fluoropropan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1454907-54-0
(4S,5R)-5-[4-(6-dimethylaminomethylpyridin-3-yl)phenyl]-4-fluoromethyl-2,2-dimethyloxazolidine-3-carboxylic acid tert-butyl ester

: 1085159-07-4
(1R,2S)-2-amino-1-[4-(6-dimethylaminomethylpyridin-3-yl)phenyl]-3-fluoropropan-1-ol

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 2h;

Reference yield:

: 1052114-46-1
tert-butyl ((1R,2S)-3-fluoro-1-hydroxy-1-(4-iodophenyl)propan-2-yl)carbamate

: 1085159-07-4
(1R,2S)-2-amino-1-[4-(6-dimethylaminomethylpyridin-3-yl)phenyl]-3-fluoropropan-1-ol

Guidance literature:: Multi-step reaction with 7 steps

1: toluene-4-sulfonic acid / dichloromethane / 2 h / 20 °C / Cooling with ice

2: potassium acetate; bis-triphenylphosphine-palladium(II) chloride / 1,4-dioxane / Reflux

3: caesium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 3 h / 90 °C / Inert atmosphere

4: potassium hydroxide; methanol / 48 h / 65 °C

5: diisopropylamine; triphenylphosphine / tetrahydrofuran; ethyl acetate / 14 h / 20 °C

6: dimethylsulfide borane complex / tetrahydrofuran; toluene / 16 h / 0 - 65 °C

7: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

With methanol; bis-triphenylphosphine-palladium(II) chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; dimethylsulfide borane complex; potassium acetate; caesium carbonate; toluene-4-sulfonic acid; diisopropylamine; triphenylphosphine; trifluoroacetic acid; potassium hydroxide; In tetrahydrofuran; 1,4-dioxane; 1,2-dimethoxyethane; dichloromethane; water; ethyl acetate; toluene;

Reference yield:

: 1454906-58-1
(4S,5R)-4-fluoromethyl-5-(4-iodophenyl)-2,2-dimethyloxazolidine-3-carboxylic acid tert-butyl ester

: 1085159-07-4
(1R,2S)-2-amino-1-[4-(6-dimethylaminomethylpyridin-3-yl)phenyl]-3-fluoropropan-1-ol

Guidance literature:: Multi-step reaction with 6 steps

1: potassium acetate; bis-triphenylphosphine-palladium(II) chloride / 1,4-dioxane / Reflux

2: caesium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 3 h / 90 °C / Inert atmosphere

3: potassium hydroxide; methanol / 48 h / 65 °C

4: diisopropylamine; triphenylphosphine / tetrahydrofuran; ethyl acetate / 14 h / 20 °C

5: dimethylsulfide borane complex / tetrahydrofuran; toluene / 16 h / 0 - 65 °C

6: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

With methanol; bis-triphenylphosphine-palladium(II) chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; dimethylsulfide borane complex; potassium acetate; caesium carbonate; diisopropylamine; triphenylphosphine; trifluoroacetic acid; potassium hydroxide; In tetrahydrofuran; 1,4-dioxane; 1,2-dimethoxyethane; dichloromethane; water; ethyl acetate; toluene;