6-(2-fluoro-phenyl)-8-(6-oxy-[2,6]naphthyridin-1-yl)-pyrido[2,3-b]pyrazine

Base Information

Chemical Name:6-(2-fluoro-phenyl)-8-(6-oxy-[2,6]naphthyridin-1-yl)-pyrido[2,3-b]pyrazine
CAS No.:1398057-34-5
Molecular Formula:C₂₁H₁₂FN₅O
Molecular Weight:369.358
Hs Code.:

Synonyms:6-(2-fluoro-phenyl)-8-(6-oxy-[2,6]naphthyridin-1-yl)-pyrido[2,3-b]pyrazine

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Chemical Property of 6-(2-fluoro-phenyl)-8-(6-oxy-[2,6]naphthyridin-1-yl)-pyrido[2,3-b]pyrazine

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Technology Process of 6-(2-fluoro-phenyl)-8-(6-oxy-[2,6]naphthyridin-1-yl)-pyrido[2,3-b]pyrazine

There total 6 articles about 6-(2-fluoro-phenyl)-8-(6-oxy-[2,6]naphthyridin-1-yl)-pyrido[2,3-b]pyrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1353969-98-8
1-chloro-[2,6]naphthyridine 6-oxide

: 1398057-31-2
[6-(2-fluorophenyl)pyrido[2,3-b]pyrazin-8-yl]-boronic acid

: 1398057-34-5
6-(2-fluoro-phenyl)-8-(6-oxy-[2,6]naphthyridin-1-yl)-pyrido[2,3-b]pyrazine

Guidance literature:: With sodium hydrogencarbonate; bis-triphenylphosphine-palladium(II) chloride; In water; N,N-dimethyl-formamide; at 80 ℃; for 16h; Inert atmosphere;

Reference yield:

: 80935-77-9
1,2-dihydro-2,6-naphthyridin-1-one

: 1398057-34-5
6-(2-fluoro-phenyl)-8-(6-oxy-[2,6]naphthyridin-1-yl)-pyrido[2,3-b]pyrazine

Guidance literature:: Multi-step reaction with 3 steps

1: trichlorophosphate / chlorobenzene / 16 h / 100 °C

2: peracetic acid; acetic acid / ethyl acetate / 18 h / 20 °C

3: sodium hydrogencarbonate / bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide; water / 16 h / 80 °C / Inert atmosphere

With peracetic acid; sodium hydrogencarbonate; acetic acid; trichlorophosphate; bis-triphenylphosphine-palladium(II) chloride; In water; ethyl acetate; N,N-dimethyl-formamide; chlorobenzene;

Reference yield:

: 1398057-29-8
8-chloro-6-(2-fluoro-phenyl)-pyrido[2,3-b]pyrazine

: 1398057-34-5
6-(2-fluoro-phenyl)-8-(6-oxy-[2,6]naphthyridin-1-yl)-pyrido[2,3-b]pyrazine

Guidance literature:: Multi-step reaction with 2 steps

1: bis(pinacol)diborane; potassium acetate / bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran / 16 h / 80 °C / Inert atmosphere

2: sodium hydrogencarbonate / bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide; water / 16 h / 80 °C / Inert atmosphere

With potassium acetate; sodium hydrogencarbonate; bis(pinacol)diborane; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; water; N,N-dimethyl-formamide;