(S)-4-<<<5-ethyl-4-(4-fluorophenyl)-2-(1-methylethyl)-6-phenyl-3-pyridinyl>methoxy>methoxyphosphinyl>-3-hydroxybutanoic acid methyl ester

Base Information

Chemical Name:(S)-4-<<<5-ethyl-4-(4-fluorophenyl)-2-(1-methylethyl)-6-phenyl-3-pyridinyl>methoxy>methoxyphosphinyl>-3-hydroxybutanoic acid methyl ester
CAS No.:135454-84-1
Molecular Formula:C₂₉H₃₅FNO₆P
Molecular Weight:543.572
Hs Code.:

Synonyms:(S)-4-<<<5-ethyl-4-(4-fluorophenyl)-2-(1-methylethyl)-6-phenyl-3-pyridinyl>methoxy>methoxyphosphinyl>-3-hydroxybutanoic acid methyl ester

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Chemical Property of (S)-4-<<<5-ethyl-4-(4-fluorophenyl)-2-(1-methylethyl)-6-phenyl-3-pyridinyl>methoxy>methoxyphosphinyl>-3-hydroxybutanoic acid methyl ester

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Technology Process of (S)-4-<<<5-ethyl-4-(4-fluorophenyl)-2-(1-methylethyl)-6-phenyl-3-pyridinyl>methoxy>methoxyphosphinyl>-3-hydroxybutanoic acid methyl ester

There total 14 articles about (S)-4-<<<5-ethyl-4-(4-fluorophenyl)-2-(1-methylethyl)-6-phenyl-3-pyridinyl>methoxy>methoxyphosphinyl>-3-hydroxybutanoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 135427-20-2
(S)-4-<<<5-ethyl-4-(4-fluorophenyl)-2-(1-methylethyl)-6-phenyl-3-pyridinyl>methoxy>methoxyphosphinyl>-3-<<(1,1-dimethylethyl)diphenylsilyl>oxy>butanoic acid methyl ester

: 135454-84-1
(S)-4-<<<5-ethyl-4-(4-fluorophenyl)-2-(1-methylethyl)-6-phenyl-3-pyridinyl>methoxy>methoxyphosphinyl>-3-hydroxybutanoic acid methyl ester

Guidance literature:: With tetrabutyl ammonium fluoride; acetic acid; In tetrahydrofuran; for 19h; Ambient temperature;
DOI:10.1021/jm00113a019

Reference yield:

: 459-57-4
4-fluorobenzaldehyde

: 135454-84-1
(S)-4-<<<5-ethyl-4-(4-fluorophenyl)-2-(1-methylethyl)-6-phenyl-3-pyridinyl>methoxy>methoxyphosphinyl>-3-hydroxybutanoic acid methyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: piperidine, HOAc / benzene / 22 h / Heating

2: 1.) LiN(TMS)2 / 1.) THF, -78 deg C, 1 h, 2.) THF, 1.5 h

3: NH₄OAc, Cu(OAc)2 / acetic acid / 24 h / Heating

4: LiAlH₄ / tetrahydrofuran / 6 h / Ambient temperature

5: 56 percent / pyridine / 16 h / 0 °C

6: 90 percent / AcOH, tetra-N-butylammonium fluoride / tetrahydrofuran / 19 h / Ambient temperature

With piperidine; pyridine; lithium aluminium tetrahydride; copper diacetate; ammonium acetate; tetrabutyl ammonium fluoride; acetic acid; lithium hexamethyldisilazane; In tetrahydrofuran; acetic acid; benzene;
DOI:10.1021/jm00113a019

Reference yield:

: 88759-56-2
(S)-bromo-3-hydroxybutyric acid methyl ester

: 135454-84-1
(S)-4-<<<5-ethyl-4-(4-fluorophenyl)-2-(1-methylethyl)-6-phenyl-3-pyridinyl>methoxy>methoxyphosphinyl>-3-hydroxybutanoic acid methyl ester

Guidance literature:: Multi-step reaction with 8 steps

1: imidazole, DMAP / dimethylformamide / Ambient temperature

2: sodium iodide / butan-2-one / 5 h / Heating

3: 75 percent / 16.5 h / 155 °C

4: bis(trimethylsilyl)trifluoroacetamide (BSTFA), trimethylsilyl bromide (TMSBr) / CH₂Cl₂ / 20 h / Ambient temperature

5: dicyclohexylcarbodiimide (DCC), pyridine / 20 h / Ambient temperature

6: 1.) TMSDEA, 2.) oxalyl chloride, DMF / 1.) CH₂Cl₂, RT, 1 h, 2.) CH₂Cl₂, 0 deg C - 20 deg C, 1 h

7: 56 percent / pyridine / 16 h / 0 °C

8: 90 percent / AcOH, tetra-N-butylammonium fluoride / tetrahydrofuran / 19 h / Ambient temperature

With pyridine; 1H-imidazole; dmap; bis(trimethylsilyl)trifluoroacetamide; oxalyl dichloride; trimethylsilyl bromide; tetrabutyl ammonium fluoride; acetic acid; N,N-dimethyl-formamide; dicyclohexyl-carbodiimide; N,N-diethyl-1,1,1-trimethylsilanamine; sodium iodide; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; butanone;
DOI:10.1021/jm00113a019